Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-24T23:08:42.107Z Has data issue: false hasContentIssue false
  • English
  • Français

Detection of Early Cancers by Quantitative Cytology

Published online by Cambridge University Press:  02 July 2020

B. Palcic ,
D. Garner  and
X.R. Sun
B. Palcic
Affiliation:
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
D. Garner
Affiliation:
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
X.R. Sun
Affiliation:
China-Canada Early Cancer Prevention Centre, TongJi Medical University, Wuhan, Hubei, PR, China
Get access

Extract

It has long been recognized that detecting cancers in their early, non-invasive stage is the best strategy to control malignant diseases. This has been best demonstrated by the example of cancer of the uterine cervix. Before screening for early signs of this malignancy, the prevalence of invasive cancer of the uterine cervix in the developed world was as high as 30 women per 100,000 and the mortality was 12-15 per 100,000 women per year, (all figures represent age standardized data). Since the introduction of cervical screening programs by Pap smears, the incidence of invasive cervical cancer and mortality due to this cancer has fallen dramatically. In British Columbia, for example, where population screening was introduced 50 years ago, the incidence and mortality have decreased several-fold and are at present below 6 and 3 per 100,000, respectively (1,2). It is believed that these figures could be even lower by encouraging more women into the program and by improving both sensitivity and specificity of the cytology.

Type
Advanced Microscopy and Image Analysis of Cells and Tissue
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 1010 - 1011
Copyright
Copyright © Microscopy Society of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

References:

1.Anderson, GH, Boyes, DA, Benedet, JL, et al. Organization and results of the cervical cytology screening program in British Columbia, 1955-1985. Br Med J 1988;296:975–978.CrossRefGoogle Scholar
2.Matisic, J, Coldman, AJ, King, S, Benedet, JL, et al. 1999 Annual Report, Cervical Screening Program of British Columbia, BCCancer Agency, 1999.Google Scholar
3.Gruner, OC. Study of the changes met with the leukocytes in certain cases of malignant disease. Br J Surg 1916;3:506–522.CrossRefGoogle Scholar
4.Nieburgs, HE, Zak, FG, Allen, DC, Reisman, H, Clardy, T. Systemic cellular changes in material from human and animal tissues. In: Transaction, 7th Ann. Mtg. Inter. Soc. Cytol. Council, 1959, pp. 137-144.Google Scholar
5.Klawe, H, Rowinski, J. Malignancy associated changes (MAC) in cells of buccal smears detected by means of objective image analysis. Acta Cytol 1974;18:30–33.Google ScholarPubMed
6.Wied, GL, Bartels, PH, Bibbo, M, Sychra, JJ. Cytomorphometric markers for uterine cancer in intermediate cells. Analyt Quant Cytol 1980;2:257–263.Google ScholarPubMed
7.Burger, G, Jutting, U, Rodenacker, K. Changes in benign cell population in cases of cervical cancer and its precursors. Analyt Quant Cytol 1981;3:261–271.Google Scholar
8.Palcic, B, MacAulay, C. Malignancy Associated Changes: Can they be employed clinically? In: Compendium on the Computerized Cytology and Histology Laboratory, Wied, GL, Bartels, PH, Rosenthal, DL, Schenck, U, Eds., Tutorials of Cytology, Chicago IL 1994, pp 157–165.Google Scholar
9.Doudkine, A, MacAulay, C, Poulin, N, Palcic, B. Nuclear texture measurements in image cytometry. Pathologica 1995;87:286–299.Google ScholarPubMed
10.Payne, PW, Sebo, TJ, Doudkine, A, Garner, D, MacAulay, C, Lam, S, LeRiche, JC, Palcic, B. Sputum screening by quantitative microscopy: A reexamination of a portion of the National Cancer Institute cooperative early lung cancer study. Mayo Clin Proc 1997;72:697–704.CrossRefGoogle ScholarPubMed
11.Palcic, B, Beveridge, J, Garner, D, Payne, P et al. Increase of sensitivity of sputum cytology using high resolution image cytometry: Field study results. Submitted to Chest, 2000.Google Scholar
12.Mairinger, T, Mikuz, G, Gschwendtner, A. Nuclear chromatin texture analysis of nonmalignant tissue can detect adjacent prostatic adenocarcinoma. Prostate 1999;41:12–19.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
13.Anderson, G, MacAulay, C, Matisic, J, Garner, D, Palcic, B. The use of an automated image cytometer for screening and quantitative assessment of cervical lesions in the British Columbia cervical smear screening programme. Cytopathology 1997;8(5):298–312.CrossRefGoogle ScholarPubMed