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Corrosion Casting in the Reproduction of the Micro-Surface Topography of Fibrillar Collagen

Published online by Cambridge University Press:  02 July 2020

P.A. Sims  and
R.M. Albrecht
P.A. Sims
Affiliation:
Dept of Animal Health and Biomedical Science, University of Wisconsin, Madison, WI, 53706
R.M. Albrecht
Affiliation:
Dept of Animal Health and Biomedical Science, University of Wisconsin, Madison, WI, 53706
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Extract

The interaction of cells with biomaterials is influenced by a number of factors including the chemical composition, surface charge, hydrophobicity, porosity and texture of the biomaterial. Changes in texture alone have been shown to result in reduced platelet adhesion on ventricular assist devices, reduced scar tissue formation around implanted prostheses, and enhanced biocompatability of vascular stents. In vitro growth of certain cells requires extracellular matrix components to provide the right physical and chemical stimuli for adherence, growth and differentiation. What role the texture of these materials plays, and the mechanisms responsible for the effects of substrate texture on the behavior of cells are not well understood. Previously we have used microcorrosion casting technology to replicate lymph node and other vasculature. More recently, we have used corrosion casting to replicate of the subendothelial matrix exposed when cells are damaged due to the passage of air emboli through a vessel.

Type
Applications and Methods of Vascular Corrosion Casting—The 3-Dimensional Microvasculature of Tissues
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 916 - 917
Copyright
Copyright © Microscopy Society of America

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References

1.Rafii, S. et al., Annals of Thoracic Surgery, 60(6)(1995)1627.CrossRefGoogle Scholar
2.Hehrlein, C. et al., Coronary Artery Disease, 6(7)(1995)581.Google Scholar
3.Taylor, S.R. and Gibbons, D.F., J. of Biomedical Materials Research, 17(2)(1983)205.CrossRefGoogle Scholar
4.Steeber, D.A. and Albrecht, R.M., in Scanning Electron Microscopy of Vascular Casts: Methods and Applications. Kluwer Academic Publishers, (1992)313.CrossRefGoogle Scholar
5.Hodde, K.C. et al., Scanning Microscopy, 4(3)(1990)693.Google Scholar
6.Goodman, S.L. et al., Biomaterials, 17(1996)2087.CrossRefGoogle ScholarPubMed
7.Sims, P.A. and Albrecht, R.M., Scanning Microscopy, 7(2)(1993)637Google Scholar