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Correlation Between Functional Recovery From Ischemia and Sarcoplasmic Reticulum Calcium Content Measured by Electron Probe MicroAnalysis

Published online by Cambridge University Press:  02 July 2020

L.S. Barrett ,
W.E. Sweet  and
C.S. Moravec
L.S. Barrett
Affiliation:
Center for Anesthesiology Research, Cleveland Clinic Foundation, Cleveland, OH44195 Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106
W.E. Sweet
Affiliation:
Center for Anesthesiology Research, Cleveland Clinic Foundation, Cleveland, OH44195
C.S. Moravec
Affiliation:
Center for Anesthesiology Research, Cleveland Clinic Foundation, Cleveland, OH44195
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Extract

Myocardial ischemia is defined as a cessation of blood flow to the heart, and reperfusion as a return to normal flow conditions following ischemia. It has been shown that contractility decreases immediately during ischemia and diastolic dysfunctiuon may persist during reperfusion. Changes in contractility can be directly attributed to intracellular Ca2+ handling, either by altering the myofilament sensitivity to calcium or by affecting Ca2+ cycling by the sarcoplasmic reticulum (SR). Previous studies have demonstrated that there are changes in intracellular Ca2+ cycling following ischemia and during reperfusion. The goals of the present study were: 1) to assess the effects of varying periods of ischemia on the size of the releasable (diastolic) SR Ca2+ store; 2) to determine whether changes in the size of the SR Ca2+ store are related to ischemia or reperfusion; 3) to correlate changes in the size of the SR Ca2+ store following ischemia with functional recovery of the heart.

Type
Quantitative Biological and Materials Microanalysis by Electrons and X-Rays
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 921 - 922
Copyright
Copyright © Microscopy Society of America 1997

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