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Clofoctol-Induced Ultrastructural Changes In Staphylococcus Aureus

Published online by Cambridge University Press:  02 July 2020

Beverly E. Maleeff ,
Stewart C. Pearson ,
David J. Payne  and
Timothy K. Hart
Beverly E. Maleeff
Affiliation:
Departments of Safety Assessment, SmithKline Beecham Pharmaceuticals King of Prussia, PA
Stewart C. Pearson
Affiliation:
Anti-Infectives Research, Collegeville, PA
David J. Payne
Affiliation:
Anti-Infectives Research, Collegeville, PA
Timothy K. Hart
Affiliation:
Departments of Safety Assessment, SmithKline Beecham Pharmaceuticals King of Prussia, PA
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Extract

Clofoctol [2-(2,4-dichlorobenzyl)-4-(tetramethyl-l,l,3,3-butyl) phenol] is a synthetic antibacterial compound with activity against both Gram-positive1 and Gram-negative2 microorganisms. Although the specific mechanism of Clofoctol action has not been fully elucidated, it is reported to alter the permeability of the cytoplasmic membrane in Bacillus subtilis, and is used clinically to treat upper respiratory tract infections in humans. Staphylococcus aureus is a major human Grampositive pathogen that causes a variety of human diseases ranging from localized skin suppuration and food poisoning to life threatening presentations such as septicemia and endocarditis. Several clinical isolates of S. aureus have recently been identified that are resistant to all currently available antibacterial therapies. Consequently, the identification of new antimicrobial targets in this organism is of paramount importance. The purpose of this study was to investigate the in vitro effects of Clofoctol on S. aureus.

Ultrastructural examination of S. aureus revealed a population of actively dividing cells.

Type
Microbiology
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1138 - 1139
Copyright
Copyright © Microscopy Society of America

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References

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