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Characterization of Monocarboxylate Transporters' expression in prostate carcinoma

Published online by Cambridge University Press:  21 August 2009

Nelma Gomes ,
José Ramón Vizcaíno ,
Céline Pinheiro  and
Fátima Baltazar
Nelma Gomes
Affiliation:
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal;
José Ramón Vizcaíno
Affiliation:
Pathology Department, Centro Hospitalar do Porto mdash;Unidade Hospital Geral Stº António, Porto, Portugal.
Céline Pinheiro
Affiliation:
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal;
Fátima Baltazar
Affiliation:
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal;

Abstract

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Highly proliferative cancer cells maintain high rates of glycolysis, producing large amounts of acids, mainly lactic acid. Despite this fact, only the interstitial pH of tumours is low, while the intracellular pH of tumours is either normal or higher than that of normal tissues. Monocarboxylate transporters (MCTs) are transmembrane proteins that, by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. MCTs play a central role in cellular metabolism and are essential for the transport of metabolically important monocarboxylates, such as lactate, across the plasma membrane.

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 15 , Supplement S3 , July 2009 , pp. 17 - 18
Copyright
Copyright © Microscopy Society of America 2009