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Blood Supply of Primary Auditory Cortex in Chinchilla: A Corrosion Cast Study

Published online by Cambridge University Press:  02 July 2020

R.J. Mount ,
R.V. Harrison ,
N. Harel ,
J. Panesar  and
H. Hamrahi
R.J. Mount
Affiliation:
Auditory Science Laboratory, Department of Otolaryngology; Brain & Behaviour Division, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, CanadaM5G 1X8
R.V. Harrison
Affiliation:
Auditory Science Laboratory, Department of Otolaryngology; Brain & Behaviour Division, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, CanadaM5G 1X8
N. Harel
Affiliation:
Auditory Science Laboratory, Department of Otolaryngology; Brain & Behaviour Division, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, CanadaM5G 1X8
J. Panesar
Affiliation:
Auditory Science Laboratory, Department of Otolaryngology; Brain & Behaviour Division, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, CanadaM5G 1X8
H. Hamrahi
Affiliation:
Auditory Science Laboratory, Department of Otolaryngology; Brain & Behaviour Division, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, CanadaM5G 1X8
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INTRODUCTION: The chinchilla animal model is widely used to study the function of the auditory system. The location of auditory cortex in the chinchilla has previously been determined both electrophysiologically and by optical imaging of intrinsic signals. The spatial resolution of functional imaging techniques which rely on changes in the BOLD (blood oxygen dependent level) signal to create images of activity (i.e., fMRI and optical imaging) are ultimately dependent on the resolution of microcirulatory control mechanisms. For example, in response to pure tone auditory stimuli, functional resolution (within cortex) of approximately 400 um has been demonstrated using optical imaging. To better understand the limits of functional imaging the present study was undertaken to explore the structure and properties of the arterial supply within auditory cortex.

METHODS: Plastic casts of the cerebral vasculature were prepared by cannulating the ascending aorta, incising the right atrium and then perfusing 50 ml heparinized PBS followed by 20 ml of Batson's #17 resin.

Type
Applications and Advances in Vascular Corrosion Casting in Microvascular Research
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 570 - 571
Copyright
Copyright © Microscopy Society of America

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References

References:

1.Harrison, R.V. et al., Hear Res (1996) 157.Google Scholar
2.Harrison, R.V. et al., Audiol Neurotol (1998) 214.CrossRefGoogle Scholar
3.Harel, N. et al., Neuroimage (2000) In press.Google Scholar