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Approaches for Understanding Dynamic Cell Movements, Cell-Cell Interactions and Tissue Shaping During Embryogenesis of the Vertebrate Body Plan

Published online by Cambridge University Press:  02 July 2020

G.C. Schoenwolf
G.C. Schoenwolf*
Affiliation:
Department of Neurobiology and Anatomy, University of Utah School of Medicine, 50 N. Medical Drive, Salt Lake City, Utah84132
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Extract

The early vertebrate embryo develops a characteristic tube-within-a-tube body plan. This plan is realized through a series of cell movements and cell-cell interactions that collectively result in tissue shaping and the formation of the three-dimensional body plan. Tissue shaping is a highly choreographed process that is under the control of the organizer--a specialized region of the embryo that is both sufficient and required for formation of the body plan. Recent technical advances have greatly increased our understanding of the role of the organizer in vertebrate embryogenesis. Such advances include the use of new cellular, molecular, genetic, and embryological approaches.

A hallmark of embryogenesis is its dynamic nature. Classically, embryos were studied in three major ways. 1) With morphological/descriptive analysis, initially involving histological procedures (stained whole mounts and serial sections cut in the three cardinal axes) and more recently electron microscopy.

Type
Applications of Imaging Techniques to the Study of Embryological Development
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1078 - 1079
Copyright
Copyright © Microscopy Society of America

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References

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8. This research was supported by the National Institutes of Health, Nos. HD 28845 and NS 18112.Google Scholar