Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-29T01:44:27.108Z Has data issue: false hasContentIssue false
  • English
  • Français

Angiotensin II Induces Translocation of Protein Kinase C α and ε in Neonatal Rat Cardiac Myocytes

Published online by Cambridge University Press:  02 July 2020

Tara A. Bullard ,
Edie Goldsmith  and
Robert L. Price
Tara A. Bullard
Affiliation:
Department of Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, 29208
Edie Goldsmith
Affiliation:
Department of Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, 29208
Robert L. Price
Affiliation:
Department of Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, 29208
Get access

Abstract

Angiotensin II (Ang II) plays an important role in heart development and has been shown to stimulate the formation of premyofibrils and differentiation of cardiac myocytes. Ang II signaling occurs through two types of receptors, the AT1 and AT2 receptors, both of which appear to play a role in the development of the myocardium. Through the use of specific Ang II receptor blockers it as been shown that blocking the AT1 receptor with Losartan (Merck) inhibits the formation of premyofibrils and sarcomere formation and that blocking the AT2 receptor with PD123,319 (Parke-Davis) inhibits the formation of trabeculae in the developing heart.

In a number of cases it has been shown that signal transduction mechanisms operate through different growth factor receptors and elicit specific responses within a cell type. Protein kinase C (PKC) is a family of closely related signal transduction enzymes that phosphorylate proteins on serine or threonine residues.

Type
Challenges of Confocal Microscopy in the 21st Century (Organized by S. Paddock)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 1016 - 1017
Copyright
Copyright © Microscopy Society of America 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literature Cite

1.Aoki, H.et al., 1998. Circ. Res. 62:524–534.Google Scholar
2.Price, R.L.et al., 1997. Dev. Biol. 192:572–584CrossRefGoogle Scholar
3.Johnson, J.A., Mochly-Rosen, D. 1995. Circ. Res. 76:654–663.CrossRefGoogle Scholar
4.Steinberg, S.F.et al., 1995. J. Mol. Cell Card. 27:141–153.CrossRefGoogle Scholar
5.Rybin, V.O., Steinberg, S.F. 1994. Circ. Res. 74:299–309.CrossRefGoogle Scholar
6. Losartan was supplied by Merck Research Laboratories.Google Scholar