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Angiogenesis in Human Gastrointestinal Tumors: An Immunohistochemical and Immuno-Electron Microscopy Study

Published online by Cambridge University Press:  02 July 2020

P. Tonino ,
H.J. Finol ,
C. Hidalgo  and
L. Sosa
P. Tonino
Affiliation:
Center for Electron Microscopy, Faculty of Sciences, Central University of Venezuela, 47114, Caracas, 1041-A, Venezuela.
H.J. Finol
Affiliation:
Center for Electron Microscopy, Faculty of Sciences, Central University of Venezuela, 47114, Caracas, 1041-A, Venezuela.
C. Hidalgo
Affiliation:
Department of Structural Biology, IVIC, 21827, Caracas, 1020-A, Venezuela.
L. Sosa
Affiliation:
Department of Histology, Faculty of Medicine, Central University of Venezuela
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Extract

Angiogenesis, the process of new blood vessels formation, is a crucial step in tumor growth and progression. Its quantitation by microvessel counting is of pronostic value in several types of malignancies, because it indicates a tumor's capacity for inducing angiogenesis. However, scarce data are available on angiogenesis in gastrointestinal tumors. Our previous work has revealed that gastrointestinal adenocarcinomas (GADC) vessels are anatomically heterogeneous structures. Additionally, it has been suggested that tumor-induced neovascularization in human carcinomas does not simply mean proliferation of capillaries, but it is also associated with certain functional changes in the vascular endothelial cells. Factor VTlI/von Willebrand factor (vWF) has been widely used for the demonstration of vascular endothelial cells as a representative marker. The aims of the present study were a) to determine whether the vascular density in GADC can be correlated to tumor aggressivness and provide prognostic information, and b) to clarify the ultrastructural immunolocalization of vWF in microvessels in the stroma of these tumors.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 576 - 577
Copyright
Copyright © Microscopy Society of America

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References

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