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AFM and Fractal Analysis of Biomaterial Microtopography

Published online by Cambridge University Press:  02 July 2020

S. Jo ,
T. Li  and
K. Park
S. Jo
Affiliation:
Purdue University, School of Pharmacy, West Lafayette, IN, 47907
T. Li
Affiliation:
Purdue University, School of Pharmacy, West Lafayette, IN, 47907
K. Park
Affiliation:
Purdue University, School of Pharmacy, West Lafayette, IN, 47907
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Extract

Although significant advances have been made in the development of biocompatible materials, currently available biomaterials still present a number of problems for in vivo applications. One of the attempts to improve the biocompatibility, especially blood-compatibility, of biomaterials has been surface modification. Typically, poly(ethylene glycol) (PEG), albumin, heparin, and phospholipid molecules are grafted to the surface to prevent protein adsorption and cell adhesion. We have been modifying biomaterial surfaces by covalent grafting of PEG and albumin. The control and modified surfaces were examined using an atomic force microscope (AFM). In this study, we examined the surface topography changes by surface modification using PEO grafting to glass as a model system.

Glass surfaces were modified with PEO using (N-triethoxysilylpropyl)-Omonomethoxy PEG urethane (PEG-Si), a PEG derivative containing a hydrophobic carbon chain and triethoxysilyl group at one end of the PEG chain. The presence of the hydrophobic carbon chain allowed self-assembly on the surface and triethoxysilyl resulted in covalent bonding to glass surfaces

Type
Biomaterials
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 926 - 927
Copyright
Copyright © Microscopy Society of America

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References

1.Dubuc, B., Quiniou, J.F., Roques-Carmes, CTricot, C, and Zucker, S.W.: Evaluating the fractal dimension of profiles, Physical Review A, 39: 1500–1512, 1989.CrossRefGoogle Scholar
2.Dubuc, B. and Dubuc, S.: Error bounds on the estimation of fractal dimension, SIAM J. Number. Anal., 33: 602–626, 1996.CrossRefGoogle Scholar