Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-12-01T00:06:16.108Z Has data issue: false hasContentIssue false
  • English
  • Français

Multiscale Microscopies in the Design and Fabrication of Novel Nanocomposites

Published online by Cambridge University Press:  02 July 2020

S.J. Eppell  and
W. Tong
S.J. Eppell
Affiliation:
Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106-7207
W. Tong
Affiliation:
Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106-7207
Get access

Abstract

The smallest apatite mineralites found in nature reside in vertebrate bone tissue. These nanoapatites participate in the formation of a protein/mineral composite with unique physical and biological properties. The composite has distinct structural features at the 10 nm, 100 nm, 1 um, 100 um, and 1 cm length scales. We analyzed the natural material on the 1-1000 nm length scale with the purpose of setting the design criteria for synthetically duplicating the material. Using a biomimetic motif, we synthesized nanomineralites with size and shape approximately equal to the natural material.

We show that our synthetic mineralites compare with the natural apatites. Recently the average size of naturally occurring mineralites in mature bovine bone was shown to be 12 nm X 10 nm X 0.61 nm. Similar experiments on 1-3 week old bovine bone mineralites showed an average size of9nm X 6nm X 2.0 nm. Within a standard deviation, the length and width of the two populations are equal.

Type
Advances in Imaging Techniques for Biomaterlals (Organized by S. Eppel)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 112 - 113
Copyright
Copyright © Microscopy Society of America 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Eppell, S.J., Tong, W., Katz, J.L., Spearing, L., Glimcher, M.J., J Orthop Res, in pressGoogle Scholar

2. 1Tanahashi, M., Yao, T., Kokubo, T., Minoda, M., Miyamototo, T., Nakamura, T., Yamamuro, T., J. Am. Ceram. Soc. 77(1994)2805.CrossRefGoogle Scholar

3. We thank the NIH AR45 664-02 and the Whitaker Foundation for their generous support.Google Scholar