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The Hair Follicle Bulge: A Niche for Adult Stem Cells

Published online by Cambridge University Press:  05 July 2011

Hilda Amalia Pasolli
Hilda Amalia Pasolli
Affiliation:
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
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Abstract

Adult stem cells (SCs) are essential for tissue homeostasis and wound repair. They have the ability to both self-renew and differentiate into multiple cell types. They often reside in specialized microenvironments or niches that preserve their proliferative and tissue regenerative capacity. The murine hair follicle (HF) has a specialized and permanent compartment—the bulge, which safely lodges SCs and provides the necessary molecular cues to regulate their function. The HF undergoes cyclic periods of destruction, regeneration, and rest, making it an excellent system to study SC biology.

Keywords

skinadult stem cellhair folliclesniche
Type
Research Article
Information
Microscopy and Microanalysis , Volume 17 , Issue 4 , August 2011 , pp. 513 - 519
Copyright
Copyright © Microscopy Society of America 2011

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References

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