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Expression and Localization of Renal Endothelin-1, Endotehlin Receptors and Endothelin Converting Enzyme in Human Renal Biopsy with Rejection after Kidney Transplantation

Published online by Cambridge University Press:  02 July 2020

M. Kinjo ,
J. Papadimitriou ,
C. Drachenberg ,
M. R. Weir  and
C. Wei
M. Kinjo
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
J. Papadimitriou
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
C. Drachenberg
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
M. R. Weir
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
C. Wei
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
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Extract

Endothelin (ET-1) is a potent renal and systemic vasoconstrictor and sodium regulating peptide. Endothelin synthesis in the kidney have been reported in glomerulus endothelial, epithelial and mesangial cells as well as in inner medullary collecting duct. Factors stimulating the production of endothelin include shear stress, hypoxia, vasoactive agents and cytokines. Endothelin binding to ET-A receptor in vascular smooth muscle cells stimulates vasoconstriction.

Renal graft rejection is a major problem after kidney transplantation with severe renal damage and renal vasoconstriction. We hypothesized that renal tissue level of endothelin-1, endothelin receptors and endothelin converting enzyme (ECE) may increase in renal tissue with rejection after kidney transplantation. Therefore, the current study was designed to determine the endothelin-1 and endothelin receptors (ET-A and ET-B) as well as endothelin converting enzyme level by immunohistochemical staining (IHCS) in human renal tissue with rejection after kidney transplantation.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 610 - 611
Copyright
Copyright © Microscopy Society of America

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References

References:

1.Simonson, M. S., et al. Kidney Int. (1998) 54, 960–971.CrossRefGoogle Scholar
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5. This research was supported in part by grants from the NIH (HL03174 & HL61299, C. Wei), AHAMD, NKF and University of Maryland School of Medicine.Google Scholar