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Enhancement of Natriuretic Peptides in Rejected Human Renal Graft

Published online by Cambridge University Press:  02 July 2020

H. Song ,
J. Papadimitriou ,
C. Drachenberg ,
M. R. Weir  and
C. Wei
H. Song
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
J. Papadimitriou
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
C. Drachenberg
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
M. R. Weir
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
C. Wei
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
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Extract

Natriuretic peptides include atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). ANP, BNP and CNP are structure related but genetic distinct 1 natriuretic peptide family. ANP and BNP are cardiac cell origin and CNP are endothelial cell and kidney origin. Natriuretic peptides have potent vasoactive and natriuretic actions through generation of cGMP. On the other hand, renal graft rejection is major problem after kidney transplantation with severe renal damage and renal vasoconstriction. We hypothesized that renal tissue level of natriuretic peptides increase in renal graft rejection through compensatory mechanism. Therefore, the present study was designed to determine the expression of natriuretic peptides by immunohistochemical staining (IHCS) in human renal tissue with rejection and compare with normal renal tissue.

Human renal biopsy (n=5) were obtained after kidney transplantation with mild and moderate renal rejection. Normal kidney biopsy was obtained during nephrectomy. ANP, BNP and CNP levels in renal tissue were determined by IHCS.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 602 - 603
Copyright
Copyright © Microscopy Society of America

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References

References:

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5. This research was supported in part by grants from the NIH (HL03174 & HL61299, C. Wei), AHAMD, NKF and University of Maryland School of Medicine.Google Scholar