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Electron Microscopic Analysis of Cerebral Aneurysms

Published online by Cambridge University Press:  02 July 2020

M. Grove-Sullivan ,
H. Yonas  and
S. Watkins
M. Grove-Sullivan
Affiliation:
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261
H. Yonas
Affiliation:
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261
S. Watkins
Affiliation:
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261
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Extract

A cerebral aneurysm is a dome or sac-like structure budding from weakened arterial walls in the brain. Cerebral aneurysms have no known specific cause currently. Considering the risks of surgery, when surgery should be performed on unruptured aneurysms is a very controversial issue. Some clinicians feel that an aneurysm should be surgically removed immediately upon discovery regardless of the size, if surgery is possible. While others feel that small aneurysms should be watched or treated with endovascular insertion of soft platinum coils, avoiding the risks associated with any brain surgery. To further study this question examination was done of specimens from surgical clip ligation of middle cerebral artery aneurysms and normal specimens.

Specimens of ruptured and unruptured aneurysm as well as normal artery removed from surgical patients were immediately preserved in cold 2.5% glutaraldehyde in 0.1 M PBS. The specimens were rinsed in PBS, post-fixed in 1% Osmium Tetroxide with 0.1% potassium ferricyanide,

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 586 - 587
Copyright
Copyright © Microscopy Society of America

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References

References:

1.Weibers, D.O. et al., New England Journal of Medicine 304( 1981)696.CrossRefGoogle Scholar
2.Redekop, G. et al., Journal of Neurosurgery 89(1998)539CrossRefGoogle Scholar