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The Efects of Spaceflight on Mitochondria in Human Lymphocytes (Jurkat).

Published online by Cambridge University Press:  02 July 2020

Heide Schatten  and
Marian Lewis
Heide Schatten
Affiliation:
Dept. of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, MO65211
Marian Lewis
Affiliation:
Microgravity Biotechnology Laboratory, University of Alabama in Huntsville, Huntsville, Alabama35899
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Extract

Spaceflight induced mitochondrial alterations have been reported for muscle and may be associated with altered physiological functions in space. Mitochondrial alterations are also indicative of preapoptotic events which are seen in greater amounts in cells exposed to spaceflight when compared with cells cultured at 1 g. Preapoptotic mitochondrial changes include alterations of processes at the inner mitochondrial membrane and can result in changes in mitochondrial volume. Higher amounts of oxidative stress during space flight may be one of the causes for changes which lead to apoptosis. Jurkat cells flown on the STS-76 space shuttle mission showed an increase in the number of cells with apoptotic bodies early in the mission and a time-dependent, microgravity-related increase in the Fas/APO-1 cell death factor. Here we investigated the morphology of mitochondria in Jurkat cells exposed to spaceflight during the STS-76 mission.

Type
Blood/Immunology
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1118 - 1119
Copyright
Copyright © Microscopy Society of America

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References

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