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Abeta Induces Abnormal Cytoskeletal Dynamics which are Reversible Upon Peptide Removal

Published online by Cambridge University Press:  28 September 2012

A. G. Henriques ,
S. I. Vieira  and
O. A. B. da Cruz e Silva
A. G. Henriques
Affiliation:
Neuroscience Lab, Center for Cell Biology, Health Sciences Dept. and Biology Dept, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal
S. I. Vieira
Affiliation:
Neuroscience Lab, Center for Cell Biology, Health Sciences Dept. and Biology Dept, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal
O. A. B. da Cruz e Silva
Affiliation:
Neuroscience Lab, Center for Cell Biology, Health Sciences Dept. and Biology Dept, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal

Abstract

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Alzheimer´s disease (AD) is characterized by extensive neuronal loss in brain areas related to memory and cognitive functions. Central to the neurodegenerative process is a peptide termed Abeta. The latter is the main component of senile plaques, one of the histopathological hallmarks of AD, and derives from proteolytic processing of the Alzheimer´s amyloid precursor protein (APP). Among the alterations induced by Abeta is increased cellular oxidative stress, imbalanced protein phosphorylation and cytoskeletal abnormalities, all factors that contribute to neuronal death.

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 18 , Supplement S5: Portuguese Supplement , August 2012 , pp. 23 - 24
Copyright
Copyright © Microscopy Society of America 2012