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3D-Morphometry of the Microvascular Architecture in Normal Human Tissues, Precanceroses, and Primary Tumors: Quantitative Corrosion Casting Studies

Published online by Cambridge University Press:  02 July 2020

M. A. Konerding ,
W. Malkusch ,
E. Fait  and
A. Gaumann
M. A. Konerding
Affiliation:
Institute of Anatomy, Johannes Gutenberg-University Mainz, D-55099, Mainz
W. Malkusch
Affiliation:
Carl Zeiss Vision GmbH, D-85399, Hallbergmoos
E. Fait
Affiliation:
Institute of Anatomy, Johannes Gutenberg-University Mainz, D-55099, Mainz
A. Gaumann
Affiliation:
Institute of Pathology, University Clinics Mainz, D-55131, Mainz
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Extract

The important question as to whether the vascular architecture of an individual tumor is tumor type specific has been controversial. We have recently shown using a simple and accurate technique for 3D-measurements in microcorrosion casts that at least experimental tumors develop a characteristic vascular network. There is strong evidence that the basic vascular architecture is determined by the tumor cells themselves. However, for human primary tumors and their metastases as well as their possible precanceroses no data are available until today.

Therefore we studied the microvascular architecture of different colorectal carcinomas and adenomas as well as the vascularity of different segments of the colon and rectum. For this, parameters defining the microvascular unit were analysed on 3D reconstructed images as recently described.Comparisons of the quantified parameters within a given segment of the colon as well as group comparisons of all segments did not reveal any significant inter-individual difference.

Type
Applications and Advances in Vascular Corrosion Casting in Microvascular Research
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 566 - 567
Copyright
Copyright © Microscopy Society of America

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References

References:

1.Malkusch, W, Konerding, MA, Klapthor, B, Bruch, J (1995) A simple and accurate method for 3.-D measurements in microcorrosion casts illustrated with tumour vascularization. Anal Cell Pathol 9, 69–81.Google ScholarPubMed
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