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Stippling the Skin: Generation of Anatomical Periodicityby Reaction-Diffusion Mechanisms

Published online by Cambridge University Press:  11 July 2009

D. J. Headon  and
K. J. Painter
D. J. Headon*
Affiliation:
The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh, Midlothian, EH25 9PS, UK
K. J. Painter
Affiliation:
Department of Mathematics and Maxwell Institute for Mathematical Sciences, School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK
*
[email protected][email protected]
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Abstract

During vertebrate development cells acquire different fates depending largely on their location in the embryo. The definition of a cell's developmental fate relies on extensive intercellular communication that produces positional information and ultimately generates an appropriately proportioned anatomy. Here we place reaction-diffusion mechanisms in the context of general concepts regarding the generation of positional information during development and then focus on these mechanisms as parsimonious systems for positioning anatomical structures relative to one another. In particular, we discuss the evidence for reaction-diffusion systems operating in the developing skin to yield the periodic arrangements of hairs and feathers and discuss how best to bring together experimental molecular biology and numerical simulations to yield a more complete understanding of the mechanisms of development and natural variation.

Keywords

reaction-diffusionpattern formationfeatherhairplacode
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 4 , Issue 4: Morphogenesis , 2009 , pp. 83 - 102
Copyright
© EDP Sciences, 2009

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