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INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia–CORRECTED VERSION

Published online by Cambridge University Press:  28 July 2009

TERESA TORRALVA ,
MARÍA ROCA ,
EZEQUIEL GLEICHGERRCHT ,
PABLO LÓPEZ  and
FACUNDO MANES
TERESA TORRALVA*
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
MARÍA ROCA
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
EZEQUIEL GLEICHGERRCHT
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina
PABLO LÓPEZ
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
FACUNDO MANES
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
*
*Correspondence and reprint requests to: Teresa Torralva, Instituto de Neurología Cognitiva (INECO), Castex 3293 (1425), Buenos Aires, Argentina. E-mail: [email protected]
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Abstract

Although several brief sensitive screening tools are available to detect cognitive dysfunction, few have been developed to quickly assess executive functioning (EF) per se. We designed a new brief tool to evaluate EF in neurodegenerative diseases. Patients with an established diagnosis of behavioral variant frontotemporal dementia (bvFTD; n = 22), Alzheimer disease (AD; n = 25), and controls (n = 26) were assessed with a cognitive screening test, the INECO Frontal Screening (IFS), and EF tests. Clinical Dementia Rating Scale (CDR) scores were obtained for all patients. Internal consistency of the IFS was very good (Cronbach’s alpha = .80). IFS total (out of 30 points) was 27.4 (SD = 1.6) for controls, 15.6 (SD = 4.2) for bvFTD, and 20.1 (SD = 4.7) for AD. Using a cutoff of 25 points, sensitivity of the IFS was 96.2%, and specificity 91.5% in differentiating controls from patients with dementia. The IFS correlated significantly with the CDR and executive tasks. The IFS total discriminated controls from demented patients, and bvFTD from AD. IFS is a brief, sensitive, and specific tool for the detection of executive dysfunction associated with neurodegenerative diseases. The IFS may be helpful in the differential diagnosis of FTD and AD. (JINS, 2009, 15, 777–786.)

Keywords

NeuropsychologyCognitionDysexecutionFrontotemporal dementiaAlzheimer diseaseDifferential diagnosis
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 5 , September 2009 , pp. 777 - 786
Copyright
Copyright © The International Neuropsychological Society 2009

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References

REFERENCES

Abusamra, V., Miranda, M.A., & Ferreres, A. [Evaluación de la iniciación e inhibición verbal en español. Adaptación y normas del test de Hayling]. Revista Argentina de Neuropsicología, 9, 19–32.Google Scholar
Baddeley, A.D., & Hitch, G. (1974). Working memory. In Bower, G.H. (Ed.), The psychology of learning and motivation: Advances in research and theory (Vol. 8, pp. 47–89). New York: Academic Press.Google Scholar
Burgess, P.W., & Shallice, T. (1997b). The Hayling and Brixton Tests. Thurston, Suffolk: Thames Valley Test Company.Google Scholar
Burgess, P., & Shallice, T. (1997a). The Hayling Test. Northern Speech Services & National Rehabilitation Services Inc.Google Scholar
Castiglioni, S., Pelati, O., Zuffi, M., Somalvico, F., Marino, L., Tentorio, T., et al. (2006). The Frontal Assessment Battery does not differentiate frontotemporal dementia from Alzheimer disease. Dementia and Geriatric Cognitive Disorders, 22, 125–131.CrossRefGoogle ScholarPubMed
Clark, L., & Manes, F. (2004). Social and emotional decision-making following frontal lobe injury. Neurocase, 10, 398–403.CrossRefGoogle ScholarPubMed
Clark, L., Manes, F., Antoun, N., Sahakian, B.J., & Robbins, T.W. (2003). The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage. Neuropsychologia, 41, 1474–1183.Google Scholar
Cullen, B., O’Neill, B., Evans, J.J., Coen, R.F., & Lawlor, B.A. (2007). A review of screening tests for cognitive impairment. Journal of Neurology, Neurosurgery, and Psychiatry, 78, 790–799.CrossRefGoogle ScholarPubMed
Cummings, J.L. (1993). Frontal-subcortical circuits and human behavior. Archives of Neurology, 50, 873–880.CrossRefGoogle ScholarPubMed
Dubois, B., Slachevsky, A., Litvan, I., & Pillon, B. (2000). The FAB: A frontal assessment battery at bedside. Neurology, 55, 1621–1626.CrossRefGoogle ScholarPubMed
Ettlin, T., & Kischka, U. (1999). Bedside frontal lobe testing. The “frontal lobe score”. In Miller, B.L. & Cummings, J.L. (Eds.), The human frontal lobes. New York, NY: The Guilford Press.Google Scholar
Folstein, M.F., Folstein, S.E., McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.Google Scholar
Funahashi, S. (2001) Neuronal mechanism of executive control by the prefrontal cortex. Neuroscience Research, 39, 147–165.CrossRefGoogle ScholarPubMed
Fuster, J.M. (1997). The prefrontal cortex (3rd ed.) New York: Raven Press.Google Scholar
Graham, N., Bak, T., & Hodges, J.R. (2003). Corticobasal degeneration as a cognitive disorder. Movement Disorders, 18, 1224–1232.CrossRefGoogle ScholarPubMed
Guedj, E., Allali, G., Goetz, C., Le Ber, I., Volteau, M., Lacomblez, L., et al. (2008). Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: A SPECT study in frontotemporal dementia. Journal of the Neurological Sciences, 273, 84–87.CrossRefGoogle ScholarPubMed
Hodges, J.R. (1994). Cognitive assessment for clinicians. Oxford: Oxford University Press.Google Scholar
Hodges, J.R. (2001). Frontotemporal dementia (Pick’s disease): Clinical features and assessment. Neurology, 56, S6–S10.CrossRefGoogle ScholarPubMed
Hodges, J.R., & Miller, B. (2001a). The neuropsychology of frontal variant frontotemporal dementia and semantic dementia. Introduction to the special topic papers: Part II. Neurocase, 7, 113–121.CrossRefGoogle Scholar
Hodges, J.R., & Miller, B. (2001b). The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers: Part I. Neurocase, 7, 31–35.Google Scholar
Hughes, C.P., Berg, L., Danzinger, W.L., Coben, L.A., & Martin, R.L. (1982). A new clinical scale for the staging of dementia. British Journal of Psychiatry, 140, 566–572.Google Scholar
Iavarone, A., Ronga, B., Pellegrino, L., Loré, E., Vitaliano, S., Galeone, F., et al. (2004). The Frontal Assessment Battery (FAB): Normative data from an Italian sample and performances of patients with Alzheimer’s disease and frontotemporal dementia. Functional Neurology, 19, 191–195.Google ScholarPubMed
Lezak, M.D. (1995). Neuropsychological assessment. Oxford, UK: Oxford University Press.Google Scholar
Lima, C.F., Meireles, L.P., Fonseca, R., Castro, S.L., & Garrett, C. (2008). The Frontal Assessment Battery (FAB) in Parkinson’s disease and correlations with formal measures of executive functioning. Journal of Neurology, 255, 1756–1761.Google Scholar
Lipton, A.M., Ohman, K.A., Womack, K.B., Hynan, L.S., Ninman, E.T., & Lacritz, L.H. (2005). Subscores of the FAB differentiate frontotemporal lobar degeneration from AD. Neurology, 65, 726–731.Google Scholar
Luria, A.R. (1966). Higher cortical function in man. London: Tavistock.Google Scholar
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., et al. (2002). Decision-making processes following damage to the prefrontal cortex. Brain, 125, 624–639.Google Scholar
Mathuranath, P.S., Nestor, P.J., Berrios, G.E., Rakowicz, W., & Hodges, J.R. (2000). A brief cognitive test battery to differentiate Alzheimer’s disease and frontotemporal dementia. Neurology, 55, 1613–1620.Google Scholar
Milner, B. (1971). Interhemispheric differences in the localization of psychological processes in man. British Medical Bulletin, 27, 272–277.CrossRefGoogle ScholarPubMed
Neary, D., Snowden, J.S., Gustafson, L., Passant, U., Stuss, D., Black, S., et al. (1998). Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology, 51, 1546–1554.CrossRefGoogle ScholarPubMed
Nelson, H.E. (1976). A modified card sorting test sensitive to frontal lobe deficits. Cortex, 12, 313–324.CrossRefGoogle Scholar
Nestor, P.J., Scheltens, P., & Hodges, J.R. (2006). Advances in the early detection of Alzheimer’s disease. Nature Medicine, 10, S34–S41.Google Scholar
Oguro, H., Yamaguchi, S., Abe, S., Ishida, Y., Bokura, H., & Kobayashi, S. (2006). Differentiating Alzheimer’s disease from subcortical vascular dementia with the FAB test. Journal of Neurology, 253, 1490–1494.CrossRefGoogle ScholarPubMed
Partington, J.E., & Leiter, R.G. (1949). Partington’s Pathway Test. The Psychological Center Bulletin, 1, 9–20.Google Scholar
Reichenberg, A., Harvey, P.D., Bowie, C.R., Mojtabai, R., Rabinowitz, J., Heaton, R.K., et al. (2008). Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophrenia Bulletin, [Epub ahead of print].Google Scholar
Roth, R.M., & Saykin, A.J. (2004). Executive dysfunction in attention-deficit/hyperactivity disorder: Cognitive and neuroimaging findings. The Psychiatric Clinics of North America, 27, 83–89.Google Scholar
Rothlind, J.C., & Brandt, J. (1993). A brief assessment of frontal and subcortical functions in dementia. Journal of Neuropsychiatry and Clinical Neurosciences, 5, 73–77.Google Scholar
Royall, D.R., Mahurin, R.K., & Gray, K.F. (1992). Bedside assessment of executive cognitive impairment: The executive interview. Journal of American Geriatrics Society, 40, 1221–1226.CrossRefGoogle ScholarPubMed
Santangelo, G., Vitale, C., Trojano, L., Verde, F., Grossi, D., & Barone, P. (2009) Cognitive dysfunctions and pathological gambling in patients with Parkinson’s disease. Movement Disorders, 24, 899–905Google Scholar
Slachevsky, A., Villalpando, J.M., Sarazin, M., Hahn-Barma, V., Pillon, B., & Dubois, B. (2004). Frontal Assessment Battery and differential diagnosis of frontotemporal dementia and Alzheimer disease. Archives of Neurology, 61, 1104–1107.CrossRefGoogle ScholarPubMed
Stuss, D.T., & Benson, D.F. (1986). The frontal lobes. New York: Raven Press.Google Scholar
Stuss, D.T., Bisschop, S.M., Alexander, M.P., Levine, B., Katz, D., & Izukawa, D. (2001). The Trail Making Test: A study in focal lesion patients. Psychological Assessment, 13, 230–239.Google Scholar
Stuss, D.T., & Levine, B. (2002). Adult clinical neuropsychology: Lessons from studies of the frontal lobes. Annual Review of Psychology, 53, 401–433.Google Scholar
Torralva, T., Kipps, C.M., Hodges, J.R., Clark, L., Bekinschtein, T., Roca, M., et al. (2007). The relationship between affective decision-making and theory of mind in the frontal variant of fronto-temporal dementia. Neuropsychologia, 45, 342–349.CrossRefGoogle ScholarPubMed
Varma, A.R., Snowden, J.S., Lloyd, J.J., Talbot, P.R., Mann, D.M., & Neary, D. (1999). Evaluation of the NINCDS-ADRA criteria in the differentiation of Alzheimer disease and frontotemporal dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 66, 184–188.Google Scholar
Wechsler, D. (1987). Wechsler Memory Scale-Revised. New York: Psychological Corporation.Google Scholar
Williams-Gray, C.H., Foltynie, T., & Brayne, C. (2007). Evolution of cognitive dysfunction in an incident Parkinson’s disease cohort. Brain, 130, 1787–1798.CrossRefGoogle Scholar
Yoshida, H., Terada, S., Sato, S., Kishimoto, Y., Ata, T., Ohshima, E., et al. (2009). Frontal assessment battery and brain perfusion imaging in early dementia. Dementia and Geriatric Cognitive Disorders, 27, 133–138.Google Scholar
Zakzanis, K., Leach, L., & Freedman, M. (1998). Structural and functional meta-analytic evidence for fronto-subcortical system deficit in progressive supranuclear palsy. Brain and Cognition, 38, 283–296.Google Scholar