Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-30T19:14:01.448Z Has data issue: false hasContentIssue false
  • English
  • Français

A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease

Published online by Cambridge University Press:  01 September 2004

JOANNE M. HAMILTON ,
DAVID P. SALMON ,
DOUGLAS GALASKO ,
DEAN C. DELIS ,
LAWRENCE A. HANSEN ,
ELIEZER MASLIAH ,
RONALD G. THOMAS  and
LEON J. THAL
JOANNE M. HAMILTON
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California
DAVID P. SALMON
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California
DOUGLAS GALASKO
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Neurology Service, Veterans Affairs San Diego Healthcare System, La Jolla, California
DEAN C. DELIS
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California Psychology Service, Veterans Affairs San Diego Healthcare System, La Jolla, California
LAWRENCE A. HANSEN
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Department of Pathology, University of California, San Diego, La Jolla, California
ELIEZER MASLIAH
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Department of Pathology, University of California, San Diego, La Jolla, California
RONALD G. THOMAS
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California
LEON J. THAL
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Neurology Service, Veterans Affairs San Diego Healthcare System, La Jolla, California
Get access Rights & Permissions [Opens in a new window]

Abstract

Little is known about possible differences in the memory deficits that occur in Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We compared 24 autopsy-confirmed DLB and 24 age-, education-, and MMSE-matched autopsy-confirmed AD patients on the California Verbal Learning Test (CVLT) and the Wechsler Memory Scale-Revised Logical Memory subtest. The DLB and AD groups were similarly impaired on CVLT Total Learning (Trials 1–5) and Long Delayed Free Recall, but the DLB group demonstrated relative improvement in Savings scores and on recognition testing compared to the AD group. Likewise, the patient groups were equally impaired on Logical Memory immediate and delayed recall, but the DLB group's Saving scores were significantly better than those of the AD patients. These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients. (JINS, 2004, 10, 689–697.)

Keywords

Dementia with Lewy bodiesAlzheimer's diseaseMemory
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 5 , September 2004 , pp. 689 - 697
Copyright
2004 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Albin, R.L., Minoshima, S., D'Amato, C.J., Frey, K.A., Kuhl, D.A., & Sima, A.A.F. (1996). Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology, 47, 462–466.CrossRefGoogle Scholar
Ballard, C., Patel, A., Oyebode, F., & Wilcock, G.K. (1996). Cognitive decline in patients with Alzheimer's disease, vascular dementia, and senile dementia of the Lewy body type. Age and Aging, 25, 209–213.CrossRefGoogle Scholar
Barber, R., Ballard, C., McKeith, I.G., Gholkar, A., & O'Brien, J.T. (2000). MRI volumetric study of dementia with Lewy bodies: A comparison with AD and vascular dementia. Neurology, 54, 1304–1309.CrossRefGoogle Scholar
Barber, R., McKeith, I.G., Ballard, C., Gholkar, A., & O'Brien, J.T. (2001). A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: Magnetic resonance imaging volumetric study. Dementia & Geriatric Cognitive Disorders, 12, 198–205.CrossRefGoogle Scholar
Braak, H., Del Tredici, K.D., Rüb, U., de Vos, R.A.I., Jansen Steur, E.N.H., & Braak, E. (2003). Staging of brain pathology related to sporadic Parkinson's disease. Neurobiology of Aging, 24, 197–211.CrossRefGoogle Scholar
Butters, N., Wolfe, J., Martone, M., Granholm, E., & Cermak, L. (1985). Memory disorders associated with Huntington's disease: Verbal recall, verbal recognition and procedural memory. Neuropsychologia, 23, 729–743.CrossRefGoogle Scholar
Butters, N., Wolfe, J., Granholm, E., & Martone, M. (1986). An assessment of verbal recall, recognition and fluency abilities in patients with Huntington's Disease. Cortex, 22, 11–32.CrossRefGoogle Scholar
Calderon, J., Perry, R.J., Erzinclioglu, S.W., Berrios, G.E., Dening, T.R., & Hodges, J.R. (2001). Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 70, 157–164.CrossRefGoogle Scholar
Connor, D.J., Salmon, D.P., Sandy, T.J., Galasko, D., Hansen, L.A., & Thal, L.J. (1998). Cognitive profiles of autopsy-confirmed Lewy body variant vs. pure Alzheimer's disease. Archives of Neurology, 55, 994–1000.CrossRefGoogle Scholar
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B.A. (1987). California Verbal Learning Test. New York: Psychological Corporation.
Delis, D.C., Massman, P.J., Butters, N., Salmon, D.P., Cermak, L.S., & Kramer, J.H. (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders. Psychological Assessment, 3, 19–26.CrossRefGoogle Scholar
Doubleday, E.K., Snowden, J.S., Varma, A.R., & Neary, D. (2002). Qualitative performance characteristics differentiate dementia with Lewy bodies and Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 72, 602–607.CrossRefGoogle Scholar
Förstl, H., Burns, A., Luthert, P., Cairns, N., & Levy, R. (1993). The Lewy-body variant of Alzheimer's disease: Clinical and pathological findings. British Journal of Psychiatry, 162, 385–392.CrossRefGoogle Scholar
Galasko, D., Katzman, R., Salmon, D.P., & Hansen, L. (1996). Clinical and neuropathological findings in Lewy body dementias. Brain and Cognition, 31, 166–175.CrossRefGoogle Scholar
Gomez-Tortosa, E., Newell, K., Irizarry, M., & Hyman, B.T. (1998). Clinical and neuropathological features of dementia with Lewy bodies. American Journal of Alzheimer's Disease, 13, 284–290.CrossRefGoogle Scholar
Graham, C., Ballard, C., & Saad, K. (1997). Variables which distinguish patients fulfilling clinical criteria for dementia with Lewy bodies from those with Alzheimer's disease. International Journal of Geriatric Psychiatry, 12, 314–318.3.0.CO;2-7>CrossRefGoogle Scholar
Granholm, E., Wolfe, J., & Butters, N. (1985). Affective-arousal factors in the recall of thematic stories by amnesic and demented patients. Developmental Neuropsychology, 1, 317–333.CrossRefGoogle Scholar
Hansen, L., Salmon, D., Galasko, D.R., Masliah, E., Katzman, R., DeTeresa, R., Thal, L.J., Pay, M.M., Hofstetter, R., Klauber, M., Rice, V., Butters, N., & Alford, M. (1990). The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity. Neurology, 40, 1–8.CrossRefGoogle Scholar
Hansen, L.A. & Samuel, W. (1997). Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies. Neurology, 48, 126–132.CrossRefGoogle Scholar
Hashimoto, M., Kitagaki, H., Imamura, T., Hirono, N., Shimomura, T., Kazui, H., Tanimukai, S., Hanihara, T., & Mori, E. (1998). Medial temporal and whole-brain atrophy in dementia with Lewy bodies: A volumetric MRI study. Neurology, 51, 357–362.CrossRefGoogle Scholar
Heyman, A., Fillenbaum, G.G., Gearing, M., Mirra, S.S., Welsh-Bohmer, K.A., Peterson, B., & Pieper, C. (1999). Comparison of Lewy body variant of Alzheimer's disease with pure Alzheimer's disease: Consortium to establish a registry for Alzheimer's disease, part XIX. Neurology, 52, 1839–1844.CrossRefGoogle Scholar
Hohl, U., Tiraboschi, P., Hansen, L., Thal, L.J., & Corey-Bloom, J. (2002). Diagnostic accuracy of dementia with Lewy bodies. Archives of Neurology, 57, 347–351.Google Scholar
Hyman, B.T., Van Hoesen, G.W., & Damasio, A.R. (1990). Memory-related neural systems in Alzheimer's disease: An anatomic study. Neurology, 40, 1721–1730.CrossRefGoogle Scholar
Lang, C.J.G., Majer, M., Balan, P., & Reischies, F.M. (2000). Recall and recognition in Huntington's disease. Archives of Clinical Neuropsychology, 15, 361–371.CrossRefGoogle Scholar
Langlais, P.J., Thal, L.J., Hansen, L.A., Galasko, D., Alford, M., & Masliah, E. (1993). Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies. Neurology, 43, 1927–1934.CrossRefGoogle Scholar
Lennox, G., Lowe, J., Landon, M., Byrne, E.J., Mayer, R.J., & Godwin-Austen, R.B. (1989). Diffuse Lewy body disease: Correlative neuropathology using anti-ubiquitin immunocytochemistry. Journal of Neurology, Neurosurgery & Psychiatry, 52, 1236–1247.CrossRefGoogle Scholar
Levy, R., Eagger, S., & Griffiths, M. (1994). Lewy bodies and response to Tacrine in Alzheimer's disease. Lancet, 343, 176–176.CrossRefGoogle Scholar
Lippa, C.F., Johnson, R., & Smith, T.W. (1998). The medial temporal lobe in dementia with Lewy bodies: A comparative study with Alzheimer's disease. Annals of Neurology, 43, 102–106.CrossRefGoogle Scholar
Lippa, C.F., Smith, T.W., & Swearer, J.M. (1994). Alzheimer's disease and Lewy body disease: A comparative clinicopathological study. Annals of Neurology, 35, 81–88.CrossRefGoogle Scholar
Lopez, O.L., Hamilton, R.L., Becker, J.T., Wisniewski, S., Kaufer, D.I., & DeKosky, S.T. (2000). Severity of cognitive impairment and the clinical diagnosis of AD with Lewy bodies. Neurology, 54, 1780–1787.CrossRefGoogle Scholar
Martone, M., Butters, N., Payne, M., Becker, J.T., & Sax, D.S. (1984). Dissociations between skill learning and verbal recognition in amnesia and dementia. Archives of Neurology, 41, 965–970.CrossRefGoogle Scholar
Martone, M., Butters, N., & Trauner, D. (1986). Some analyses of forgetting of pictorial material in amnesic and demented patients. Journal of Clinical and Experimental Neuropsychology, 8, 161–178.CrossRefGoogle Scholar
Massman, P.J., Delis, D.C., & Butters, N. (1993). Does impaired primacy recall equal impaired long-term storage? Serial position effects in Huntington's disease and Alzheimer's disease. Developmental Neuropsychology, 9, 1–15.Google Scholar
McKeith, I.G., Galasko, D., Kosaka, K., Perry, E.K., Dickson, D.W., Hansen, L.A., Salmon, D.P., Lowe, J., Mirra, S.S., Byrne, E.J., Lennox, G., Quinn, N.P., Edwardson, J.A., Ince, P.G., Bergeron, C., Burns, A., Miller, B.L., Lovestone, S., Collerton, D., Jansen, E.N., Ballard, C., de Vos, R.A., Wilcock, G.K., Jellinger, K.A., & Perry, R.H. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology, 47, 1113–1124.CrossRefGoogle Scholar
Merdes, A.R., Hansen, L.A., Jeste, D.V., Galasko, D., Hofstetter, C.R., Ho, G.J., Thal, L.J., & Corey-Bloom, J. (2003). Influence of Alzheimer's pathology on clinical diagnostic accuracy in dementia with Lewy bodies. Neurology, 60, 1586–1590.CrossRefGoogle Scholar
Minoshima, S., Foster, N.L., Sima, A., Frey, K.A., Albin, R.L., & Kuhl, D.E. (2001). Alzheimer's disease versus dementia with Lewy bodies: Cerebral metabolic distinction with autopsy confirmation. Annals of Neurology, 50, 358–365.CrossRefGoogle Scholar
Moss, M.B., Albert, M.S., Butters, N., & Payne, M. (1986). Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease, and alcoholic Korsakoff's syndrome. Archives of Neurology, 43, 239–246.CrossRefGoogle Scholar
Olichney, J.M., Galasko, D., Salmon, D.P., Hofstetter, C.R., Hansen, L.A., Katzman, R., & Thal, L.J. (1998). Cognitive decline is faster in Lewy body variant than in Alzheimer's disease. Neurology, 51, 351–357.CrossRefGoogle Scholar
Rezaie, P., Cairns, N.J., Chadwick, A., & Lantos, P.L. (1996). Lewy bodies are located preferentially in limbic areas in diffuse Lewy body disease. Neuroscience Letters, 12, 114.CrossRefGoogle Scholar
Salmon, D.P., Galasko, D., Hansen, L.A., Masliah, E., Butters, N., Thal, L.J., & Katzman, R. (1996). Neuropsychological deficits associated with diffuse Lewy body disease. Brain and Cognition, 31, 148–165.CrossRefGoogle Scholar
Shimomura, T., Mori, E., Yamashita, H., Imamura, T., Hirono, N., Hashimoto, M., Tanimukai, S., Kazui, H., & Hanihara, T. (1998). Cognitive loss in dementia with Lewy bodies and Alzheimer disease. Archives of Neurology, 55, 1547–1552.CrossRefGoogle Scholar
Snodgrass, J.G. & Corwin, J. (1988). Pragmatics of measuring recognition memory: Applications to dementia and amnesia. Journal of Experimental Psychology: General, 117, 34–50.CrossRefGoogle Scholar
Squire, L.R. & Zola-Morgan, S. (1991). The medial temporal lobe memory system. Science, 253, 1380–1386.CrossRefGoogle Scholar
Tiraboschi, P., Hansen, L.A., Alford, M., Sabbagh, M.N., Schoos, B., Masliah, E., Thal, L.J., & Corey-Bloom, J. (2000). Cholinergic dysfunction in diseases with Lewy bodies. Neurology, 54, 407–411.CrossRefGoogle Scholar
Tröster, A.I., Butters, N., Salmon, D.P., Cullum, C.M., Jacobs, D., Brandt, J., & White, R.F. (1993). The diagnostic utility of savings scores: Differentiating Alzheimer's and Huntington's diseases with Logical Memory and Visual Reproduction tests. Journal of Clinical and Experimental Neuropsychology, 15, 773–788.CrossRefGoogle Scholar
Walker, Z., Allen, R.L., Shergill, S., & Katona, C.L. (1997). Neuropsychological performance in Lewy body dementia and Alzheimer's disease. British Journal of Psychiatry, 170, 156–158.CrossRefGoogle Scholar
Wechsler, D. (1987). Wechsler Memory Scale–Revised. New York: The Psychological Corporation.