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Serum soluble tumour necrosis factor related apoptosis-inducing ligand level and peripheral eosinophil count in patients with nasal polyposis

Published online by Cambridge University Press:  06 February 2015

A Bisgin ,
H Eyigor ,
U Osma ,
M D Yilmaz  and
A D Yalcin
A Bisgin*
Affiliation:
Medical Genetics Department of Balcali Clinics and Hospitals, Faculty of Medicine, Cukurova University, Adana, Turkey Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Sweden
H Eyigor
Affiliation:
Department of Otorhinolaryngology, Antalya Training and Research Hospital, Turkey
U Osma
Affiliation:
Department of Otorhinolaryngology, Antalya Training and Research Hospital, Turkey
M D Yilmaz
Affiliation:
Department of Otorhinolaryngology, Antalya Training and Research Hospital, Turkey
A D Yalcin
Affiliation:
Department of Internal Medicine, Allergy and Clinical Immunology Unit, Antalya Training and Research Hospital, Turkey Genomics Research Center, Academia Sinica, Taipei, Taiwan
*
Address for correspondence: Dr Atil Bisgin, Medical Genetics Department of Balcali Clinics and Hospitals, Faculty of Medicine, Cukurova University, Adana, Turkey E-mail: [email protected]
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Abstract

Background:

Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. Eosinophilic inflammation plays an important role in the pathogenesis. This study aimed to investigate soluble tumour necrosis factor related apoptosis-inducing ligand levels and eosinophil count in nasal polyposis patients.

Methods:

The study was performed on 24 adult nasal polyposis patients and 24 age-matched healthy individuals. The patients had not received any medical or surgical treatment. Pre-operative computed tomography scans were assessed using the Lund–MacKay grading system, and soluble tumour necrosis factor related apoptosis-inducing ligand levels were measured with a sandwich enzyme-linked immunosorbent assay.

Results:

Compared with controls, eosinophil levels in nasal polyposis patients were increased (p = 0.024), but there was no significant difference in soluble tumour necrosis factor related apoptosis-inducing ligand levels (p = 0.529). The Lund–Mackay mean grading was 12.43 ± 6.9. There was no correlation between soluble tumour necrosis factor related apoptosis-inducing ligand level and Lund–Mackay grading and eosinophil count.

Conclusion:

There was no relationship between soluble tumour necrosis factor related apoptosis-inducing ligand level and blood eosinophil or clinical markers; however, soluble tumour necrosis factor related apoptosis-inducing ligand level remains of interest for future studies.

Keywords

Nasal PolypsEosinophilsBiological Markers
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 3 , March 2015 , pp. 250 - 253
Copyright
Copyright © JLO (1984) Limited 2015 

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