Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-18T16:56:51.344Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasmablastic lymphoma of the larynx: report of two cases

Published online by Cambridge University Press:  19 September 2012

K Stephenson ,
S Peer ,
D Govender  and
J J Fagan
K Stephenson*
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
S Peer
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
D Govender
Affiliation:
Division of Anatomical Pathology, University of Cape Town, South Africa
J J Fagan
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
*
Address for correspondence: Dr Kate Stephenson, Division of Otorhinolaryngology, University of Cape Town, H-53 Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To report two cases of laryngeal plasmablastic lymphoma, a rare and relatively recently described form of non-Hodgkin's lymphoma. It has not previously been described in the larynx, nor associated with upper airway obstruction.

Case reports:

We describe the clinicopathological features of two such cases in human immunodeficiency virus positive patients, and we discuss their unusual presentations and diagnostic features.

Conclusion:

When evaluating a laryngeal tumour, plasmablastic lymphoma and other non-Hodgkin's lymphomata should be considered as differential diagnoses, particularly in the setting of a high prevalence of human immunodeficiency virus infection. Biopsy with detailed histopathological and immunohistochemical evaluation is recommended to ensure correct diagnosis and optimal management.

Keywords

LarynxPlasmablastic LymphomaLymphoma, Non-Hodgkin'sLymphoma, B-CellHuman Immunodeficiency Virus
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 1 , January 2013 , pp. 96 - 99
Copyright
Copyright © JLO (1984) Limited 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Delecluse, HJ, Anagnostopoulos, I, Dallenbach, F, Hummel, M, Marafioti, T, Schneider, U et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 1997;89:1413–20CrossRefGoogle ScholarPubMed
2 Castillo, JJ, Reagan, JL. Plasmablastic lymphoma: a systematic review. Scientific World Journal 2011;11:687–96CrossRefGoogle ScholarPubMed
3 Castillo, J, Pantanowitz, L, Dezube, B. HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases. Am J Hematology 2008;83:804–9CrossRefGoogle ScholarPubMed
4 Castillo, JJ, Winer, ES, Stachurski, D, Perez, K, Jabbour, M, Milani, C et al. Clinical and pathological differences between human immunodeficiency virus-positive and human immunodeficiency virus-negative patients with plasmablastic lymphoma. Leuk Lymphoma 2010;51:2047–53Google Scholar
5 Carbone, A. AIDS-related non-Hodgkin's lymphomas: from pathology and molecular pathogenesis to treatment. Hum Pathol 2002;33:392–404 Google Scholar
6 Rafaniello Raviele, P, Pruneri, G, Maiorano, E. Plasmablastic lymphoma: a review. Oral Diseases 2009;15:38–45 Google Scholar
7 Bohlius, J, Schmidlin, K, Costagliola, D, Fätkenheuer, G, May, M, Caro-Murillo, AM et al. Incidence and risk factors of HIV-related non-Hodgkin's lymphoma in the era of combination antiretroviral therapy: a European multicohort study. Antivir Ther 2009;14:1065–74Google Scholar
8 Thirlwell, C, Sarker, D, Stebbing, J, Bower, M. Acquired immunodeficiency syndrome-related lymphoma in the era of highly active antiretroviral therapy. Clin Lymphoma 2003;4:86–92 Google Scholar
9 Carbone, A, Cesarman, E, Spina, M, Gloghini, A, Schulz, TF. HIV-associated lymphomas and gamma-herpesviruses. Blood 2009;113:1213–24CrossRefGoogle ScholarPubMed
10 Carbone, A, Gloghini, A. Plasmablastic lymphoma: one or more? Am J Hematol 2008;83:763–4CrossRefGoogle ScholarPubMed
11 Dong, HY, Scadden, DT, de Leval, L, Tang, Z, Isaacson, PG, Harris, NL. Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. Am J Surg Pathol 2005;29:1633–41Google Scholar
12 Castillo, JJ, Winer, ES, Stachurski, D, Perez, K, Jabbour, M, Milani, C et al. Prognostic factors in chemotherapy-treated patients with HIV-associated plasmablastic lymphoma. Oncologist 2010;15:293–9CrossRefGoogle ScholarPubMed
13 Guan, B, Zhang, X, Ma, H, Zhou, H, Zhou, X. A meta-analysis of highly active anti-retroviral therapy for treatment of plasmablastic lymphoma. Ann Saudi Med 2010;30:123–8Google Scholar