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Olfactory neural tumours—the role of external beam radiotherapy

Published online by Cambridge University Press:  29 June 2007

N. J. Slevin ,
C. J. R. Irwin ,
S. S. Banerjee ,
N. K. Gupta  and
W. T. Farrington
N. J. Slevin*
Affiliation:
Department of Radiotherapy, Christie Hospital, Manchester, UK
C. J. R. Irwin
Affiliation:
Department of Radiotherapy, Christie Hospital, Manchester, UK
S. S. Banerjee
Affiliation:
Department of Pathology, Christie Hospital, Manchester, UK
N. K. Gupta
Affiliation:
Department of Radiotherapy, Christie Hospital, Manchester, UK
W. T. Farrington
Affiliation:
Department of Surgery, Christie Hospital, Manchester, UK
*
Address for correspondence: Dr N. J. Slevin, Consultant Radiotherapist and Oncologist, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX Fax: 0161-446-3352
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Abstract

Olfactory neuroblastoma is an uncommon tumour arising in the nasal cavity or paranasal sinuses. We report the management of nine cases treated with external beam radiotherapy subsequent to sureery, either attempted definitive removal or biopsy only. Recent refinements in pathologicalevaluation of these tumours are discussed. Seven cases were deemed classical olfactory neuroblastoma whilst two were classified as neuroendocrine carcinoma. The clinical features, radirap technique and variable natural history are presented. Seven of eight patients treatecall were controlled locally, with a minimumfollow-up of two years. Three patients developedcervica lymph node disease and three patients died of systemic metastatic disease. Suggestios are made as to which patients should have en-bloc resection rather than definitive radiotherapy.

Keywords

NeuroblastomaOlfactory nerveRadiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 11 , November 1996 , pp. 1012 - 1016
Copyright
Copyright © JLO (1984) Limited 1996

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References

Anavi, Y., Bahar, M., Ben-Bassat, M. (1989) Report of a case and review of the literatul factory neuroblastoma. Journal of Oral Maxillofacial Surgery 47: 514–517.CrossRefGoogle Scholar
Biller, H. F., Lawson, W., Sachdev, V. P., Som, P. (1990) Esthesioneuroblastoma: surgical treatment without radiation. Laryngoscope 100: 1199–1201.CrossRefGoogle ScholarPubMed
Canty, P. (1979) Olfactory neuroblastoma: long term survival. Journal of Laryngology and Otology 93: 285–292.CrossRefGoogle ScholarPubMed
Chapman, P., Carter, R. L., Clifford, P. (1981) The diagnosisand surgical management of olfactory neuroblastoma: The role of craniofacial resection. Journal of Laryngology and Otology 95: 785–799.CrossRefGoogle Scholar
Daly, N. J., Voigt, J. J., Combes, P. F. (1980) Diagnosis and treatment of olfactory neuroblastomas in seven patients. International Journal of Radiation Oncology, Biology and Physics 6: 1735–1738.CrossRefGoogle ScholarPubMed
Kadish, S., Goodman, M., Wang, C. C. (1976) A clinical analysis of 17 cases, olfactory neuroblastoma. Cancer 37: 1571–1576.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Levine, P. A., McLean, W. C., Cantrell, R. W. (1986) Esthesioneuroblastoma: The University of Virginia Experience 1960–1985. Laryngoscope 96: 742–746.CrossRefGoogle ScholarPubMed
Logue, J. P., Banerjee, S. S., Slevin, N. J., Vasanthan, S. (1991) Neuroendocrine carcinomas of the larynx. Journal of Laryngology and Otology 105: 1031–1035.CrossRefGoogle ScholarPubMed
Michaels, L. (1989) Head and Neck Tumours. Chap. 6 Recent advances in histopathology, no 14 (Anthony, P. P., MacSween, R. N. M., ed.) Churchill Livingstone, Edinburgh, pp 107–112.Google Scholar
Morita, A., Ebersold, M. J., Olsen, K. D., Foote, R. L., Lewis, J. E., Quast, L. M. (1993) Esthesioneuroblastoma: prognosis and management. Neurosurgery 32: 706–715.CrossRefGoogle Scholar
Ordonez, N. G., Mackay, B. (1993) Neuroendocrine tumours of the nasal cavity. In Pathology Annual 2 (Rosen, P. P., Fechner, R. E., ed.) Appleton and Lange, Norwalk (Conn.) pp 77–113.Google Scholar
O'Connor, T. A., McLean, P., Juillard, G. J. F., Parker, R. G. (1989) Olfactory neuroblastoma. Cancer 63: 2426–2428.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Pape, H., Wurm, R., Schmitt, G. (1990) Pathogenese und Klinik der Ästhesioneuroblastome, Literaturüberblick und Analyse von 235 Fällen. Tumoriagnostik und Therapie 11: 237–242.Google Scholar
Parsons, J. T., Mendenhall, W. M., Mancuso, A. A., Cassisi, N. J., Million, R. R. (1988) Malignant tumors of the nasal cavity and ethmoid and sphenoid sinuses. International Journal of Radiation Oncology, Biology and Physics 14: 11–22.CrossRefGoogle ScholarPubMed
Sakata, K. -I., Aoki, Y., Karasawa, K., Nakagawa, K., Hasezawa, K., Muta, N., Terahara, A., Onogi, Y., Sasaki, Y., Akanuma, A., Mohri, N. (1993) Esthesioneuroblastoma, A report of seven cases. Acta Oncologica 32: 399–302.CrossRefGoogle ScholarPubMed
Silva, E. G., Butler, J. J., Mackay, B., Goepfert, H. (1982) Neuroblastomas and neuroendocrine carcinomas of the nasal cavity, a proposed new classification. Cancer 50: 2388–2405.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Urdaneta, N., Fischer, J. J., Knowlton, A. (1988) Olfactory neuroblastoma, observations on seven patients treated with adiation therapy and review of the literature. American ournal of Clinical Oncology 11: 672–678.CrossRefGoogle Scholar