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Co-Phenylcaine Spray: can we improve the taste? A randomised, double-blind, crossover study

Published online by Cambridge University Press:  07 July 2017

S Bailey ,
B Panizza ,
P Cabot  and
B Wallwork
S Bailey*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia
B Panizza
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
P Cabot
Affiliation:
School of Pharmacy, Pharmacy Australia Centre of Excellence, University of Queensland, Brisbane, Australia
B Wallwork
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia
*
Address for correspondence: Dr Stuart John Bailey, Department of Otolaryngology – Head and Neck Surgery, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, Brisbane, Queensland 4104, Australia Fax: +61 731 762 427 E-mail: [email protected]
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Abstract

Objective:

Co-Phenylcaine Forte is a nasal spray routinely prescribed by otolaryngologists in Australia. The taste of Co-Phenylcaine Forte is typically described as unpleasant. This study sought to improve the overall patient experience associated with Co-Phenylcaine Forte by generating a Co-Phenylcaine Forte formulation, referred to as Co-Phenylcaine Zest, which contains an added vanilla flavour and masking agent.

Methods:

Participants were randomised to receive two actuations of Co-Phenylcaine Forte in each nostril followed by two actuations of Co-Phenylcaine Zest, or vice versa. There was a 6–36-hour washout period between each treatment. After the administration of each spray, participants completed a questionnaire to rate various sensory attributes of each formulation on seven-point ordinal scales. Patients reported their overall formulation preference after receiving both treatments.

Results:

A total of 86 participants completed the trial. Seventy-four per cent of patients preferred Co-Phenylcaine Zest, 21 per cent preferred Co-Phenylcaine Forte and 5 per cent had no preference (p < 0.001). The satisfaction score associated with Co-Phenylcaine Zest was 1.22 points greater than with Co-Phenylcaine Forte (p < 0.001).

Conclusion:

A novel formulation of Co-Phenylcaine Forte was created by adding a flavour and a masking agent; this formulation was preferred by most patients.

Keywords

AnestheticsLocalDecongestantsEndoscopyNasal Mucosa
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 2 , February 2018 , pp. 138 - 142
Copyright
Copyright © JLO (1984) Limited 2017 

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References

1 Douglas, R, Hawke, L, Wormald, P. Topical anaesthesia before nasendoscopy: a randomized controlled trial of co-phenylcaine compared with lignocaine. Clin Otolaryngol 2006;31:33–5Google Scholar
2 Lennox, P, Hern, J, Birchall, M, Lund, V. Local anaesthesia in flexible nasendoscopy. A comparison between cocaine and co-phenylcaine. J Laryngol Otol 1996;110:540–2CrossRefGoogle ScholarPubMed
3 Smith, JC, Rockley, TJ. A comparison of cocaine and ‘co-phenylcaine’ local anaesthesia in flexible nasendoscopy. Clin Otolaryngol Allied Sci 2002;27:192–6Google Scholar
4 Georgalas, C, Sandhu, G, Frosh, A, Xenellis, J. Cophenylcaine spray vs. placebo in flexible nasendoscopy: a prospective double-blind randomised controlled trial. Int J Clin Pract 2005;59:130–3Google Scholar
5 Frosh, AC, Jayaraj, S, Porter, G, Almeyda, J. Is local anaesthesia actually beneficial in flexible fibreoptic nasendoscopy? Clin Otolaryngol Allied Sci 1998;23:259–62CrossRefGoogle ScholarPubMed
6 BITREX® - Johnson Matthey Fine Chemicals. In: http://www.jmfinechemicals.com/bitrex/ [1 October 2016]Google Scholar
7 Conlin, A, McLean, L. Systematic review and meta-analysis assessing the effectiveness of local anesthetic, vasoconstrictive, and lubricating agents in flexible fibre-optic nasolaryngoscopy. J Otolaryngol Head Neck Surg 2008;37:240–9Google ScholarPubMed
8 Sharma, V, Chopra, H. Role of taste and taste masking of bitter drugs in pharmaceutical industries - an overview. Int J Pharm Pharm Sci 2010;2:14–18 Google Scholar