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Clofazimin in the treatment of scleroma

Published online by Cambridge University Press:  29 June 2007

M. A. Shehata  and
A. M. Salama
M. A. Shehata*
Affiliation:
Departments of Ear, Nose and Throat and Radiation Oncology, Faculty of Medicine, University of Alexandria, Egypt
A. M. Salama
Affiliation:
Departments of Ear, Nose and Throat and Radiation Oncology, Faculty of Medicine, University of Alexandria, Egypt
*
Dr Mostafa Shehata, Professor of Otolaryngology, Faculty of Medicine, Alexandria, Egypt
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Abstract

Scleroma is a chronic progressive granulomatous disease predominantly affecting the mucous membrane of the upper respiratory tract, endemic in temperate and tropical zone countries including Egypt. Many patients in early stages respond to medical treatment while others do not. In these patients an antileprotic agent Clofazimin (Lamprene®) was tried in 76 patients and the therapeutic results are very promising, especially for the early stages of the disease.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 9 , September 1989 , pp. 856 - 860
Copyright
Copyright © JLO (1984) Limited 1989

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References

Botros, G., Hamilton, P. L., Floyed, T. M., Mufti, A. and Imam, A. (1954). Scleroma in Egypt. Annals of Otology, Rhinology and Laryngology, 63: 4: 1031–1055.CrossRefGoogle ScholarPubMed
Burnas, D. W. (1968) Recognition of scleroma (Rhinoscleroma). Laryngoscope, 78: 1948–1957.Google Scholar
El-Hakeem, A., El-Samma, E. and Mossallam, I. A. (1954) Aureomycin therapy in rhinoscleroma. Journal of Laryngology and Otology, 68: 523–534.CrossRefGoogle Scholar
El-Mofty, A. (1962) Histological examination of scleroma. Annals of Otology, Rhinology and Laryngology, 71: 377–381.CrossRefGoogle ScholarPubMed
Fisher, E. R. and Dimling, C. (1965) Rhinoscleroma-light and electromicroscopic studies. Archives of Pathology, 78: 501–512.Google Scholar
Mackay, J. P. (1976) Clofazimin in dermatology. International Journal of Dermatology, 15: 140–141.CrossRefGoogle Scholar
Muzyka, M. M. and Grubina, K. M. (1972) Problems of the epidemiology of scleroma. Journal of Hygiene Epidemiology, Microbiology and Immunology, 16: 10–80.Google ScholarPubMed
New, B. G., Weed, L. A., Nicolos, D. R. et al. , (1948) Rhinoscleroma apparently cured with streptomycin. Annals of Otology, Rhinology and Laryngology, 57: 412–417.CrossRefGoogle ScholarPubMed
Reyes, E. (1946) Rhinoscleroma, observations based on study of two hundred cases. Archives of Dermatology and Syphilology, 54: 531–537.CrossRefGoogle Scholar
Ssali, C. L. K. (1975) The management of rhinoscleroma. Journal of Laryngology and Otology, 89: 91–99.CrossRefGoogle ScholarPubMed
Shehata, M. A., Sallab, R. and Mandour, M. A. (1975) Radiographic study of scleroma. Journal of Laryngology and Otology, 89: 1243–1261.CrossRefGoogle ScholarPubMed
Shum, T. K., Whitaker, C. W. and Meyer, P. R. (1982) Clinical update on rhinoscleroma. Laryngoscope, 92: 1149–1153.CrossRefGoogle ScholarPubMed
Steinberg, C. M., Clark, W. D. and Galveston, T. X. (1983) Rhinoscleroma a diagnostic challenge. Laryngoscope, 93: 866–870.CrossRefGoogle Scholar
Zwiefach, E. (1955) Rhinoscleroma. Journal of Laryngology and Otology, 69: 321–330.CrossRefGoogle ScholarPubMed