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The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring

Published online by Cambridge University Press:  29 June 2007

Nadine S. Ives Aguilera ,
M. Uusafr ,
Bruce M. Wenig  and
Susan L. Abbondanzo
Nadine S. Ives Aguilera*
Affiliation:
Departments of Otolaryngologic, Armed Forces Institute of Pathology, Washington D.C.
M. Uusafr
Affiliation:
Departments of Hematopathology, Armed Forces Institute of Pathology, Washington D.C.
Bruce M. Wenig
Affiliation:
Departments of Endocrine Pathology, Armed Forces Institute of Pathology, Washington D.C.
Susan L. Abbondanzo
Affiliation:
Departments of Hematopathology, Armed Forces Institute of Pathology, Washington D.C.
*
Address for correspondence: Nadine S. Ives Aguilera, M.D., Department of Hematopathology, AFIP, Washington D.C., 20306-6000USA Fax: 202-782-9157 E-mail: [email protected]
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Abstract

We present three cases of blastic mantle cell lymphoma with an unusual initial manifestation in Waldeyer's ring with methods for differentiating it from other blastic neoplasms of the head and neck. All cases presented with a feeling of fullness inthe area of the mass. Morphologically, the tumours were blastic with a high mitotic rate (three to nine per high power field). All were B-cell phenotype with coexpression of CD43. In all cases cyclin Dl and bcl-2 were positive and CD23 negative. Blastic mantle cell lymphoma occurring in Waldeyer's tonsillar ring may be mistaken for other high grade haematopoietic neoplasms. Immunohistochemistry and awareness of this type of lymphoma arehelpful in differentiating it from other neoplasms.

Keywords

LymphomaB cell mantleTonsil neoplasmsNasopharyngeal neoplasmsTongue neoplasms
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 10 , October 1998 , pp. 991 - 994
Copyright
Copyright © JLO (1984) Limited 1998

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Footnotes

The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Air Force, Department of the Army, or the Department of Defense.

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