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Value of autofluorescence bronchoscopy in patients with laryngeal cancer

Published online by Cambridge University Press:  09 November 2010

E Çetınkaya ,
B Veyseller ,
Y S Yildirim ,
F Aksoy ,
M A Özgül ,
A Gençoğlu  and
S Altin
E Çetınkaya
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
B Veyseller
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
Y S Yildirim*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
F Aksoy
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
M A Özgül
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
A Gençoğlu
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
S Altin
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
*
Dr Yavuz Selim Yıldırım, Haseki Egitim ve Arastirma Hastanesi, Kulak Burun Bogaz Klinigi, 34089 Fatih, Istanbul, Turkey Fax: +90 212 5103701 E-mail: [email protected]
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Abstract

Background:

Patients with squamous cell carcinoma of the head and neck constitute a high risk group for synchronous and metachronous tumours.

Objective:

This study aimed to investigate the usefulness of white light and autofluorescence bronchoscopy in the evaluation of pre-malignant and early neoplastic lesions in patients with laryngeal cancer, who are at high risk of concomitant lung cancer.

Methods:

This prospective, cross-sectional study included 30 patients who had undergone total laryngectomy for squamous cell carcinoma of the larynx. The tracheobronchial system was investigated for the presence of pre-malignant and malignant lesions, using a combination of white light and autofluorescence bronchoscopy. Biopsies were obtained from areas with a pathological appearance, and histopathological studies were performed.

Results:

All patients had a permanent tracheostomy. Light and autofluorescence bronchoscopy indicated that the tracheobronchial system was normal in 11 patients. A total of 27 biopsies was taken from the remaining 19 patients, and revealed invasive squamous cell carcinoma in one patient and pre-malignant changes in six.

Conclusion:

Bronchoscopy is a valuable and practical tool for screening patients at high risk of lung cancer, and requires minimal intervention especially in patients with a permanent tracheostomy. Of the various bronchoscopic techniques becoming available, autofluorescence bronchoscopy shows promise for the detection of pre-invasive malignant changes of the tracheobronchial system in patients previously operated upon for laryngeal cancer.

Keywords

Lung NeoplasmsAutofluorescenceBronchoscopyHead And Neck NeoplasmsCarcinoma In SituLaryngectomy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 2 , February 2011 , pp. 181 - 187
Copyright
Copyright © JLO (1984) Limited 2010

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References

1Parkin, DM, Bray, F, Ferlay, J, Pisani, P. Estimating the world cancer burden: globocan 2000. Int J Cancer 2001;94:153–6Google Scholar
2Bechtel, JJ, Petty, TL, Saccomanno, G. Five year survival and later outcome of patients with X-ray occult lung cancer detected by sputum cytology. Lung Cancer 2000;30:1–7CrossRefGoogle ScholarPubMed
3Edell, E, Lam, S, Pass, H, Miller, YE, Sutedja, T, Kennedy, T et al. Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. J Thorac Oncol 2009;4:49–54CrossRefGoogle ScholarPubMed
4Stoeckli, SJ, Zimmermann, R, Schmid, S. Role of routine panendoscopy in cancer of the upper aerodigestive tract. Otolaryngol Head Neck Surg 2001;124:208–12CrossRefGoogle ScholarPubMed
5Moro-Sibilot, D, Jeanmart, M, Lantuejoul, S, Arbib, F, Laverrière, MH, Brambilla, E et al. Cigarette smoking, preinvasive bronchial lesions, and autofluorescence bronchoscopy. Chest 2002;122:1902–8CrossRefGoogle ScholarPubMed
6Hujala, K, Sipila, J, Grenman, R. Panendoscopy and synchronous second primary tumors in head and neck cancer patients. Eur Arch Otorhinolaryngol 2005;262:17–20CrossRefGoogle ScholarPubMed
7Lam, S, MacAulay, C, leRiche, JC, Palcic, B. Detection and localization of early lung cancer by fluorescence bronchoscopy. Cancer Suppl 2000;89(suppl):2468–733.0.CO;2-V>CrossRefGoogle ScholarPubMed
8Palcic, B, Lam, S, Hung, J, MacAulay, C. Detection and localization of early lung cancer by imaging techniques. Chest 1991;99:742–3CrossRefGoogle ScholarPubMed
9Goujon, D, Zellweger, M, Radu, A, Grosjean, P, Weber, B-C, van den Bergh, H et al. In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system. J Biomed Opt 2003;8:17–25CrossRefGoogle ScholarPubMed
10Lam, S, Kennedy, T, Unger, M. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest 1998;113:696–702CrossRefGoogle ScholarPubMed
11Andersson-Engels, S, Klinteberg, C, Svanberg, K, Svanberg, S. In vivo fluorescence imaging for tissue diagnostics. Phys Med Biol 1997;42:815–24CrossRefGoogle ScholarPubMed
12Qu, J, MacAulay, C, Lam, S, Palcic, B. Laser induced fluorescence spectroscopy at endoscopy: tissue optics, Monte Carlo modeling and in vivo measurements. Opt Eng 1995;34:3334–43CrossRefGoogle Scholar
13Hung, J, Lam, S, Le Riche, JC, Palcic, B. Autofluorescence of normal and malignant bronchial tissue. Lasers Surg Med 1991;11:99–105CrossRefGoogle ScholarPubMed
14Kurie, JM, Lee, JS, Morice, RC, Walsh, GL, Khuri, FR, Broxson, A et al. Autofluorescence bronchoscopy in the detection of squamous metaplasia and dysplasia in current and former smokers. J Natl Cancer Inst 1998;90:991–5CrossRefGoogle ScholarPubMed
15Keith, RL, Miller, YE, Gemmill, RM, Drabkin, HA, Dempsey, EC, Kennedy, TC et al. Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res 2000;6:1616–25Google Scholar
16Weigel, TL, Yousem, D, Dacic, S, Kosco, PJ, Siegfried, J, Luketich, JD. Fluorescence bronchoscopic surveillance after curative surgical resection for non-small cell lung cancer. Ann Surg Oncol 2000;7:176–80CrossRefGoogle ScholarPubMed
17Pierard, P, Vermylen, P, Bosschaerts, T, Roufosse, C, Berghmans, T, Sculier, JP et al. Synchronous roentgenographically occult lung carcinoma in patients with resectable primary lung cancer. Chest 2000;117:779–85Google Scholar
18Sutedja, TG, Codrington, H, Risse, EK, Breuer, RH, van Mourik, JC, Golding, RP et al. Autofluorescence bronchoscopy improves staging of radiographically occult lung cancer and has an impact on therapeutic strategy. Chest 2001;120:1327–32CrossRefGoogle ScholarPubMed
19Kusunoki, Y, Imamura, F, Uda, H, Mano, M, Horai, T. Early detection of lung cancer with laser-induced fluorescence endoscopy and spectrofluorometry. Chest 2000;118:1776–82Google Scholar
20Kennedy, TC, Lam, S, Hirsch, FR. Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer. Oncologist 2001;6:257–62CrossRefGoogle ScholarPubMed
21Beamis, JR, Ernst, A, Simoff, M, Yung, R, Mathur, P. A multicenter study comparing autofluorescence bronchoscopy to white light bronchoscopy using a non-laser light stimulation system. Chest 2004;125:148S–49SCrossRefGoogle ScholarPubMed
22Jang, TW, Oak, CH, Chun, BK, Jung, MH. Detection of pre-invasive endobronchial tumours with D-light/autofluorescence system. J Korean Med Sci 2006;21:242–6CrossRefGoogle ScholarPubMed
23Helfritzsch, H, Junker, K, Bartel, M, Scheele, J. Differentiation of positive autofluorescence bronchoscopy findings by comparative genomic hybridization. Oncol Rep 2002;9:697–701Google ScholarPubMed
24Venmans, BJ, van Boxem, TJ, Smit, EF, Postmus, PE, Sutedja, TG. Outcome of brochial carcinoma in situ. Chest 2000;117:1572–6CrossRefGoogle Scholar
25Brambilla, E, Travis, WD, Colby, TV, Corrin, B, Shimosato, Y. The new World Health Organization classification of lung tumours. Eur Respir J 2001;18:1059–68Google Scholar
26Lee, P, Brokx, HA, Postmus, PE, Sutedja, TG. Dual digital video-autofluorescence imaging for detection of pre-neoplastic lesions. Lung Cancer 2007;58:44–9CrossRefGoogle ScholarPubMed
27Zargi, M, Fajdiga, I, Smid, L. Autofluorescence imaging in the diagnosis of laryngeal cancer. Eur Arch Otorhinolaryngol 2000;257:17–23CrossRefGoogle ScholarPubMed
28Flehinger, BJ, Melamed, MR, Zaman, MB, Heelan, RT, Perchick, WB, Martini, N. Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Memorial Sloan-Kettering study. Am Rev Respir Dis 1984;130:555–60Google ScholarPubMed
29Kennedy, TC, Franklin, WA, Prindiville, SA, Cook, R, Dempsey, EC, Keith, RL et al. High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia. Lung Cancer 2005;49:187–91CrossRefGoogle ScholarPubMed
30Vermylen, P, Pierard, P, Roufosse, C, Bosschaerts, T, Verhest, A, Sculier, JP et al. Detection of bronchial preneoplastic lesions and early lung cancer with fluorescence bronchoscopy: a study about its ambulatory feasibility under local anaesthesis. Lung Cancer 1999;25:161–8CrossRefGoogle ScholarPubMed
31Hirsch, FR, Franklin, WA, Gazdar, AF, Bunn, PA Jr.Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res 2001;7:5–22Google Scholar
32Sato, M, Sakurada, A, Sagawa, M, Minowa, M, Takahashi, H, Oyaizu, T et al. Diagnostic results before and after introduction of autofluorescence bronchoscopy in patients suspected of having lung cancer detected by sputum cytology in lung cancer mass screening. Lung Cancer 2001;32:247–53CrossRefGoogle ScholarPubMed
33Fuso, L, Pagliari, G, Boniello, V, Trove′, A, Varone, F, Longobardi, A et al. Autofluorescence bronchoscopy to identify pre-cancerous bronchial lesions. Monaldi Arch Chest Dis 2005;63:124–8CrossRefGoogle ScholarPubMed
34Ernst, A, Simoff, M, Mathur, P, Yung, R, Beamis, J. D-Light autofluorescence in the detection of premalignant airway changes. A multicenter trial. J Bronchol 2005;12:133–8CrossRefGoogle Scholar
35Venmans, BJ, van Boxem, TJ, Smit, EF, Postmus, PE, Sutedja, TG. Bronchial intraepithelial neoplastic lesions in head and neck cancer patients: results of autofluorescence bronchoscopy. Ann Otol Rhinol Laryngol 2001;110:635–8CrossRefGoogle ScholarPubMed
36Peters, EJ, Morice, R, Benner, SE, Lippman, S, Lukeman, J, Lee, JS et al. Squamous metaplasia of the bronchial mucosa and its relationship to smoking. Chest 1993;103:1429–32CrossRefGoogle ScholarPubMed
37Peto, R, Darby, S, Deo, H, Silcocks, P, Whitley, E, Doll, R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case–control studies. BMJ 2000;321:323–9Google Scholar
38Kennedy, TC, Proudfoot, SP, Franklin, WA, Merrick, TA, Saccomanno, G, Corkill, ME et al. Cytopathological analysis of sputum in patients with airflow obstruction and significant smoking histories. Cancer Res 1996;56:4673–8Google ScholarPubMed