Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-24T19:03:12.848Z Has data issue: false hasContentIssue false
  • English
  • Français

Spontaneous reversibility of damage to outer hair cells after sodium salicylate induced ototoxicity

Published online by Cambridge University Press:  19 April 2011

I de Almeida-Silva ,
J A A de Oliveira ,
M Rossato ,
F Fiacadori Salata  and
M A Hyppolito
I de Almeida-Silva
Affiliation:
Department of Speech Therapy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil
J A A de Oliveira
Affiliation:
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil
M Rossato
Affiliation:
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil
F Fiacadori Salata
Affiliation:
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil
M A Hyppolito*
Affiliation:
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil
*
Address for correspondence: Prof Dr Miguel Angelo Hyppolito, Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil Av Bandeirantes, 3900 12° Andar-Monte Alegre, Ribeirão Preto, SP, Brazil Fax: 55 (16)3602 2860 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

High sodium salicylate doses can cause reversible hearing loss and tinnitus, possibly due to reduced outer hair cell electromotility. Sodium salicylate is known to alter outer hair cell structure and function. This study determined the reversibility and cochlear recovery time after administration of an ototoxic sodium salicylate dose to guinea pigs with normal cochlear function.

Study design:

Prospective experimental investigation.

Methods:

All animals received a single 500 mg sodium salicylate dose, but with different durations of action. Function was evaluated before drug administration and immediately before sacrifice. Cochleae were processed and viewed using scanning electron microscopy.

Results:

Changes in outer hair cell function were observed to be present 2 hours after drug administration, with recovery of normal anatomy beginning after 24 hours. Subsequently, derangement and distortion of cilia reduced, with effects predominantly in row three. At 168 hours, cilia were near-normal but with mild distortions which interfered with normal cochlear physiology.

Conclusions:

Ciliary changes persisted for up to 168 hours after ototoxic sodium salicylate administration.

Keywords

Sodium SalicylateCochleaHearing LossHair Cells, Auditory, OuterOtoacoustic EmissionsMicroscopy, ElectronGuinea Pig
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 8 , August 2011 , pp. 786 - 794
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Oliveira, JAA. Audiovestibular Toxicity of Drugs, Vols I and II, 1st English edn.Boca Raton: CRC Pr I Llc, 1989;511CrossRefGoogle Scholar
2Fujimura, K, Yoshida, M, Goto, K, Mori, T, Suzuki, H. Effect of salicylate on electrically evoked otoacoustic emissions elicited in the first and third turns of the guinea pig cochlea. Acta Otolaryngol 2004;124:896–901CrossRefGoogle ScholarPubMed
3Stypulkowski, PH. Mechanisms of salicylate ototoxicity. Hear Res 1990;46:113–45CrossRefGoogle ScholarPubMed
4Shehata, WE, Brownell, WE, Dieler, R. Effects of salicylate on shape, electromotility and membrane characteristics of isolated outer hair cells from guinea pig cochlea. Acta Otolaryngol 1991;111:707–18CrossRefGoogle ScholarPubMed
5Brownell, WE, Bader, CR, Bertrand, D, Ribaupierre, Y. Evoked mechanical responses of isolated cochlear outer hair cells. Science 1985;227:194–6CrossRefGoogle ScholarPubMed
6Kachar, B, Brownell, WE, Altschuler, R, Fex, J. Electrokinetic shape changes of cochlear outer hair cells. Nature 1986;322:365–8CrossRefGoogle ScholarPubMed
7Ashmore, JF. A fast motile response in guinea-pig outer hair cells: the cellular basis of the cochlear amplifier. J Physiol 1987;388:323–47CrossRefGoogle ScholarPubMed
8Lue, JCA, Brownell, WE. Salicylate induced changes in outer hair cell lateral wall stiffness. Hear Res 1999;135:163–8CrossRefGoogle ScholarPubMed
9Dieler, R, Shehata-Dieler, WE, Richter, CP, Klinke, R. Effects of endolymphatic and perilymphatic application of salicylate in the pigeon. II. Fine structure of auditory hair cells. Hear Res 1994;74:85–98CrossRefGoogle ScholarPubMed
10Tunstall, MJ, Gale, JE, Ashmore, JF. Action of salicylate on membrane capacitance of outer hair cells from the guinea-pig cochlea. J Physiol 1995;485:739–52CrossRefGoogle ScholarPubMed
11Kakehata, S, Santos-Sacchi, J. Effects of salicylate and lanthanides on outer hair cell motility and associated gating charge. J Neurosci 1996;16:4881–9CrossRefGoogle ScholarPubMed
12Fujimura, K, Yoshida, M, Makishima, K. Effect of salicylate and short-term sound exposure on extracochlear electrically-evoked otoacoustic emissions. Acta Otolaryngol 2001;121:781–6CrossRefGoogle ScholarPubMed
13Böhmer, A. The Preyer reflex – an easy estimate of hearing function in guinea pigs. Acta Otolaryngol 1988;106:368–72CrossRefGoogle ScholarPubMed
14He, NJ, Schmiedt, RA. Fine structure of the 2F1-F2 acoustic distortion product: changes with primary level. J Acoust Soc Am 1993;94:2659–69CrossRefGoogle ScholarPubMed
15Saito, T, Manabe, Y, Honda, N, Yamada, T, Yamamoto, T, Saito, H. Semiquantitative analysis by scanning electron-microscopy of cochlear hair cell-damage by ototoxic drugs. Scanning Microsc 1995;9:271–81Google ScholarPubMed
16Cardinaal, RM, Groot, JCMJ, Huizing, EH, Veldman, JE, Smoorenburg, GF. Dose-dependent effect of 8-day cisplatin administration upon the morphology of the albino guinea pig cochlea. Hear Res 2000;144:135–46CrossRefGoogle ScholarPubMed
17Demarco, RC, Rossato, M, Oliveira, JAA, Hyppolito, MA. Histological effects of intratympanic gentamicin on the vestibular organ of guinea pigs. J Laryngol Otol 2011, in pressCrossRefGoogle ScholarPubMed
18Oliveira, JAA, Canedo, DM, Rossato, M. Otoprotection of auditory hair cells against amikacin ototoxicity. Rev Bras Otorhinolaryngolog 2002;68:7–13CrossRefGoogle Scholar
19Jastreboff, P. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Hear Res 1990;8:221–54Google ScholarPubMed
20Musiek, FE, Rintelman, WF. Current Perspectives in Audiologic Evaluation, 1st Brazilian edn [in Portuguese]. São Paulo: Manole, 2001;166–71Google Scholar
21Yang, G, Lobarinas, E, Zhang, L, Turner, J, Stolzber, GD, Salvi, R et al. Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats. Hear Res 2006;218:1–10Google Scholar
22Stewart, CE, Hudspeth, AJ. Effects of salicylate and aminoglycosides on spontaneous otoacoustic emissions in the Tockay gecko. Proc Natl Acad Sci USA 2000;9:454–59CrossRefGoogle Scholar
23Withnell, RH, Shaffer, LAE, Lilly, DJ. What drives mechanical amplification in the mammalian cochlea? Ear Hear 2002;23:49–57CrossRefGoogle ScholarPubMed
24Zenner, HP, Ernst, A. Cochlear-motor, transduction and signal-transfer tinnitus: models for three types of cochlear tinnitus. Eur Arch Otorhinolaryngol 1993;249:447–54CrossRefGoogle ScholarPubMed
25Sahley, TL, Nodar, RH. A biomechanical model of peripheral tinnitus. Hear Res 2001;152:43–54CrossRefGoogle Scholar
26Jero, J, Coling, DE, Lalwani, AK. The use of Preyer reflex in evaluation of hearing in mice. Acta Otolaryngol 2001;121:585–9CrossRefGoogle ScholarPubMed
27Jastreboff, PJ, Sasaki, CT. An animal model of tinnitus: a decade of development. Am J Otol 1994;15:19–27Google ScholarPubMed
28Tonndorf, J. Acute cochlear disorders: the combination of hearing loss, recruitment, poor speech discrimination and tinnitus. Ann Otol Rhinol Laryngol 1980;89:353–8CrossRefGoogle ScholarPubMed