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Carcinoma cuniculatum of the larynx: a rare clinicopathological entity

Published online by Cambridge University Press:  10 October 2007

R Puxeddu*
Affiliation:
Department of Otorhinolaryngology, Queen Alexandra Hospital, Portsmouth, UK
D Cocco
Affiliation:
Department of Surgical Sciences and Organ Transplantations, University of Cagliari, Cagliari, Italy
G Parodo
Affiliation:
Department of Cytomorphology, University of Cagliari, Cagliari, Italy
G Mallarini
Affiliation:
Department of Imaging, Policlinico Universitario, Cagliari, Italy
M Medda
Affiliation:
Department of Surgical Sciences and Organ Transplantations, University of Cagliari, Cagliari, Italy
P A Brennan
Affiliation:
Department of Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK
*
Address for correspondence: Mr Roberto Puxeddu, Department of Otorhinolaryngology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK. E-mail: [email protected]

Abstract

Objective:

Carcinoma cuniculatum is a rare variant of low-grade squamous cell carcinoma. We report the second case of carcinoma cuniculatum of the larynx in the literature.

Method:

Case report and review of the world literature concerning carcinoma cuniculatum of the larynx and upper aerodigestive tract.

Results:

A histologically proven carcinoma cuniculatum of the larynx is reported in a 72-year-old man. The patient underwent a supracricoid laryngectomy with crico-hyoidopexy, and was free of disease at 70 months after surgery. We emphasise the clinical presentation, histology and therapeutic approach of this rare tumour.

Conclusion:

To our knowledge this is the second report in the world literature of carcinoma cuniculatum of the larynx. Carcinoma cuniculatum of the larynx must be considered as a distinct ‘clinicopathological entity’ and close cooperation between the clinician and the pathologist is essential for the correct diagnosis of these tumour as regards to the correct classification and therapy.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2008

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References

1 Aird, I, Johnson, HD, Lennox, B, Stansfeld, AG. Epithelioma cuniculatum: a variety of squamous carcinoma peculiar to the foot. Br J Surg 1954;42:245–50CrossRefGoogle ScholarPubMed
2 Kao, GF, Graham, JH, Helwig, EB. Carcinoma cuniculatum (verrucous carcinoma of the skin). A clinicopathologic study of 46 cases with ultrastructural observations. Cancer 1982;49:2395–4033.0.CO;2-3>CrossRefGoogle ScholarPubMed
3 Bendelac, A, Grossin, M, Sigal, M, Crickx, B, Godeau, MJ, Bocquet, L et al. Epithelioma cuniculatum. Apropos of a case with review of the literature. Ann Pathol 1984;4:223–9Google ScholarPubMed
4 Schwartz, RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 1995;32:121CrossRefGoogle ScholarPubMed
5 Ho, J, Diven, DG, Butler, PJ, Tyring, SK. An ulcerating verrucous plaque on the foot. Verrucous carcinoma (epithelioma cuniculatum). Arch Dermatol 2000;136:547–8, 500–1CrossRefGoogle ScholarPubMed
6 Coldiron, BM, Brown, FC, Freeman, RG. Epithelioma cuniculatum (carcinoma cuniculatum) of the thumb: a case report and literature review. J Dermatol Surg Oncol 1986;12:1150–5CrossRefGoogle ScholarPubMed
7 Flieger, S, Owinski, T. Epithelioma cuniculatum an unusual form of mouth and jaw neoplasm [in Polish]. Czas Stomatol 1977;30:395401Google ScholarPubMed
8 Kahn, JL, Blez, P, Gasser, B, Weill-Bousson, M, Vetter, JM, Champy, M. Carcinoma cuniculatum. Apropos of 4 cases with orofacial involvement. Rev Stomatol Chir Maxillofac 1991;92:2733Google ScholarPubMed
9 Delahaye, JF, Janser, JC, Rodier, JF, Auge, B. Cuniculatum carcinoma. 6 cases and review of the literature [in French]. J Chir (Paris) 1994;131:73–8Google ScholarPubMed
10 Huault, M, Laroche, C, Levy, J, Laxenaire, A, Roucayrol, AM, Scheffer, P. Epithelioma cuniculatum. Apropos of a case in the anterior gingiva with involvement of the mandibular symphyseal bone and reconstruction using a fibular osteocutaneous flap and integrated implants. Rev Stomatol Chir Maxillofac 1998;99:143–8Google ScholarPubMed
11 Allon, D, Kaplan, I, Manor, R, Calderon, S. Carcinoma cuniculatum of the jaw: a rare variant of oral carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:601–8CrossRefGoogle ScholarPubMed
12 Gassler, N, Helmke, B, Schweigert, HG, Hassfeld, S, Otto, HF, Flechtenmacher, C. Carcinoma cuniculatum of the oral cavity. A contribution to the differential diagnosis of potentially malignant papillary lesions of mouth mucosa [in German]. Pathologe 2002;23:313–17CrossRefGoogle Scholar
13 De Petris, G, Lewin, M, Shoji, T. Carcinoma cuniculatum of the esophagus. Ann Diagn Pathol 2005;9:134–8CrossRefGoogle ScholarPubMed
14 Van Geertruyden, JP, Olemans, C, Laporte, M, Noel, JC. Verrucous carcinoma of the nail bed. Foot Ankle Int 1998;19:327–8CrossRefGoogle ScholarPubMed
15 Kraus, FT, Perezmesa, C. Verrucous carcinoma: clinical and pathological study of 105 cases involving oral cavity, larynx and genitalia. Cancer 1966;19:26383.0.CO;2-L>CrossRefGoogle ScholarPubMed
16 Eisenberg, E, Rosenberg, B, Krutchkoff, DJ. Verrucous carcinoma: a possible viral pathogenesis. Oral Surg Oral Med Oral Pathol 1985;59:52–7CrossRefGoogle ScholarPubMed
17 Noel, JC, Peny, MO, Goldschmidt, D, Verhest, A, Heenen, M, De Dobbeleer, G. Human papillomavirus type 1 DNA in verrucous carcinoma of the leg. J Am Acad Dermatol 1993;29:1036–8CrossRefGoogle ScholarPubMed
18 Petersen, CS, Sjolin, KE, Rosman, N, Lindeberg, H. Lack of human papillomavirus DNA in carcinoma cuniculatum. Acta Derm Venereol 1994;74:231–2CrossRefGoogle ScholarPubMed
19 Martin, F, Dalac, S, Lambert, D. Verrucous carcinoma. Nosologic aspects, apropos of 4 cases. Ann Dermatol Venereol 1995;122:399403Google ScholarPubMed
20 Zielonka, E, Goldschmidt, D, de Fontaine, S. Verrucous carcinoma or epithelioma cuniculatum plantare. Eur J Surg Oncol 1997;23:86–7CrossRefGoogle ScholarPubMed
21 Lever, WF, Schaumberg-Lever, G. Histopathology of the Skin, 7th edn. Philadelphia: JB Lippincott, 1990;558–9Google Scholar
22 Shanmugaratnam, K, Sobin, LK. The World Health Organization Histological Classification of Tumours of the Upper Respiratory Tract and Ear, 2nd edn. Berlin: Springer-Verlag, 1991Google Scholar
23 McKee, PH, Wilkinson, JD, Corbett, MF, Davey, A, Sauven, P, Black, MM. Carcinoma cuniculatum: a cast metastasizing to skin and lymph nodes. Clin Exp Dermatol 1981;6:613–18CrossRefGoogle ScholarPubMed