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Brain blood flow abnormalities associated with oral cocaine use

Published online by Cambridge University Press:  13 June 2014

Bankole Johnson ,
Lamk Lamki ,
Bruce Barron ,
Ralph Spiga ,
Richard Chen ,
Richard Meisch  and
Neera Khilnani
Bankole Johnson
Affiliation:
Clinical Laboratory and Experimental Alcohol Research
Lamk Lamki
Affiliation:
Prof Dept of Nuclear Medicine
Neera Khilnani
Affiliation:
University of Texas, Health Science Center at Houston, Mental Sciences Institute, 1300 Moursund, Houston, Texas 77030, USA
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Abstract

Single photon emission tomography (SPECT) is the prototypical tool for measuring cerebral blood flow (CBF) in discrete areas of the brain. Compared with when a male ‘crack’ cocaine user received placebo, oral cocaine (1mg/kg) ingestion was associated with non-uniformity of overall CBF with hypoperfusion of discrete brain regions, particularly of the frontal, temporo-parietal, basal ganglia, and thalamic areas. While these results should be viewed as preliminary, they do suggest that oral cocaine use may be associated with CBF abnormalities in ‘crack’ users.

Keywords

SPECTTc-HMPAONeuroimagingOral cocaineCerebral blood flowBrain
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 14 , Issue 2 , June 1997 , pp. 72 - 73
Copyright
Copyright © Cambridge University Press 1997

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