Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-28T00:40:02.527Z Has data issue: false hasContentIssue false

Haemophilus ducreyi

Published online by Cambridge University Press:  02 January 2015

Judy A. Daly*
Affiliation:
Microbiology Laboratories, Primary Children's Medical Center, Salt Lake City, Utah
*
Microbiology Laboratories, Primary Children's Medical Center, 32012th Avenue, Salt Lake City, UT 84103

Extract

Chancroid, or soft chancre (ulcus molle), was first differentiated from syphilis by Bassereau in 1852. The causative organism, Haemophilus ducreyi, was first described by Ducrey in 1889, although he was unable to grow the organism in vitro. The first successful culture has been attributed to Petersen (1895). Haemophilus ducreyi has been clinically associated only with genital ulcer disease and direct inoculation infections. There is no difficulty accepting Haemophilus ducreyi as a legitimate clinical and taxonomic species because it is the sole human Haemophilus species with a requirement only for X factor as determined by the porphyrin test. The emergence of Haemophilus ducreyi strains resistant to multiple antibiotics has restricted efforts to curb the spread of this increasingly prevalent sexually transmitted disease.

Type
Original Articles
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Albritton, WL: Infections due to Haemophilus species other than Haemophilus influenzae. Ann Rev Microbiol 1982;36:199216.Google Scholar
2.Hammond, GW, Slutchuk, M, Scatliff, J, et al: Epidemiologic, clinical, laboratory, and therapeutic features of an urban outbreak of chancroid in North America. Rev Infect Dis 1980;2:867879.Google Scholar
3.Kilian, M: A taxonomic study of the genus Haemophilus, with the proposal of a new species. J Gen Microbiol 1976;93:962.Google Scholar
4.Hammond, GW, Lian, CJ, Wilt, JC, et al: Determination of the hemin requirement of Haemophilus ducreyi: Evaluation of the porphyrin test and media used in the satellite growth test. J Clin Microbiol 1978;7:243246.Google Scholar
5.Plummer, FA, D'Costa, LJ, Nsanze, H, et al: Antimicrobial therapy of chancroid: Effectiveness of erythromycin. J Infect Dis 1983;148:726731.Google Scholar
6.Plummer, FA, Nsanze, H, D'Costa, LJ, et al: Single-dose therapy of chancroid with trimethoprim-sulfametrole. N Engl J Med 1983;309:6771.CrossRefGoogle ScholarPubMed
7.Sanson-LePors, MJ, Casin, I, Ortenberg, M, et al: In-vitro susceptibility of thirty strains of Haemophilus ducreyi to several antibiotics including six cephalosporins. J Antimicrob Chemother 1983;11:271280.Google Scholar
8.Tan, U, Rajan, VS, Koe, SL. et al: Chancroid, a study of500 cases over 12 months in Singapore. Asian Journal of Infectious Diseases 1977;1:2728.Google Scholar
9.Hafiz, S, Kinghorn, GR, McEntegart, MG: Chancroid in Sheffield. Br J Venn Dis 1981;57:382386.Google Scholar
10.Hannah, H, Greenwood, JR: Isolation and rapid identification of Haemophilus ducreyi. J Clin Microbiol 1982;16:861864.CrossRefGoogle ScholarPubMed
11.Lykke-Elesen, L, Larsen, L, Pedersen, TG, et al: Epidemic of chancroid in Greenland 1977-1978. Lancet 1979;1:654655.CrossRefGoogle Scholar
12.Nsanze, H, Plummer, FA, Maggwa, ABN, et al: Comparison of media for the primary isolation of Haemophilus ducreyi. Sex Transm Dis 1984;11:69.Google Scholar
13.Hammond, GW, Lian, CJ, Wilt, JC, et al: Comparison of specimen collection and laboratory techniques for isolation of Haemophilus duerni. J Clin Microbiol 1978;7:3943.Google Scholar
14.Sottneck, FO, Biddle, JW, Kraus, SJ, et al: Isolation and identification of Haemophilus ducreyi in a clinical study. J Clin Microbiol 1980;12:19701974.Google Scholar
15.Oberhofer, TR, Back, AE: Isolation and cultivation of Haemophilus ducreyi. J Clin Microbiol 1982;15:625629.CrossRefGoogle ScholarPubMed
16.Borchardt, KA, Hoke, AW: Simplified laboratory technique for diagnosis of chancroid. Arch Dermatol 1970;102:188192.CrossRefGoogle ScholarPubMed
17.Sng, EH, Lim, AL, Rajan, VS, et al: Characteristics of Haemophilus ducreyi. Br J Venn Dis 1982;58:239242.Google ScholarPubMed
18.Dienst, RB: Virulence and antigenicity of Haemophilus ducreyi. American Journal of Gonorrhea and Venereal Diseases 1948;32:289291.Google Scholar
19.Feiner, RR, Mortara, F: Infectivity of Haemophilus ducreyi for the rabbit and the development of skin hypersensitivity. American Journal of Syphilis, Gonorrhea and Venereal Diseases 1945;29:7179.Google Scholar
20.Thayer, JD, Field, FW, Perry, MI: In vitro sensitivity of Haemophilus ducreyi to several antibiotics. Antibiot Chemother 1955;5:132134.Google Scholar
21.Odumeru, JA, Wiseman, GM, Ronald, AR: Virulence factors of Haemophilus ducreyi. Infect Immun 1984;43:607611.Google Scholar
22.Singer, S, Deacon, WE: Effects of penicillin G in vitro on Haemophilus ducreyi. Health Report 1956;71:11121114.Google Scholar
23.Marmar, JL: The management of resistant chancroid in Vietnam. J Urol 1972;107:807808.Google Scholar
24.Albritton, WL, Brunton, JL, Slaney, L, et al: Plasmid-mediated sulfonamide resistance in Haemophilus ducreyi. Antimicrob Agents Chemother 1982;21:159165.CrossRefGoogle ScholarPubMed
25.Handsfield, HH, Totten, PA, Fennel, CL, et al: Molecular epidemiology of Haemophilus ducreyi infections. Ann Intern Med 1981;95:315318.Google Scholar
26.Brunton, J, Meier, M, Ehrman, N, et al: Molecular epidemiology of betalactamase specifying plasmids of Haemophilus ducreyi. Antimicrob Agents Chemother 1982;21:857863.Google Scholar
27.Brunton, J, Meier, M, Ehrman, N, et al: Plasmid-mediated ampicillin resistance in Haemophilus ducreyi. Antimicrob Agents Chemother 1979;15:294299.Google Scholar
28.Girouard, YC, MacLean, IW, Ronald, AR, et al: Synergistic antibacterial activity of clavulanic acid and amoxicillin against beta-lactamase producing strains of Haemophilus ducreyi. Antimicrob Agents Chemother 1981;20:144145.CrossRefGoogle ScholarPubMed
29.Totten, PA, Handsfield, HH, Peters, D, et al: Characterization of ampicillin resistance plasmids from Haemophilus ducreyi. Antimicrob Agents Chemother 1982;21:622627.Google Scholar
30.Odumeru, JA, Ronald, AR, Albritton, WL: Characterization of cell proteins of Haemophilus ducreyi by Polyacrylamide gel electrophoresis. J Infect Dis 1983;148:710714.Google Scholar
31.McGovern, JE Jr, Terry, PM, Huang, TSR, et al: Nosocomial infections with gentamicin-resistant Staphylococcus aureus: Plasmid analysis as an epidemiological tool. J Infect Dis 1979;140:864872.Google Scholar
32.O'Brien, TF, Ross, DG, Guzman, MA, et al: Dissemination of an antibiotic resistance plasmid in hospital patient flora. Antimicrob Agents Chemother 1980;17:537543.Google Scholar
33.Tompkins, LS, Plorde, JJ, Falkow, S: Molecular analysis of R-factors from mukiresistant nosocomial isolates. J Infect Dis 1980;141:625636.CrossRefGoogle ScholarPubMed