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Pleiotropy of p-fluorophenylalanine-resistant and antibiotic hypersensitive mutants of Pseudomonas aeruginosa

Published online by Cambridge University Press:  14 April 2009

N. W. Dunn  and
B. W. Holloway
N. W. Dunn
Affiliation:
Department of Genetics, Monash University, Clayton, Victoria 3168, Australia
B. W. Holloway
Affiliation:
Department of Genetics, Monash University, Clayton, Victoria 3168, Australia
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Mutants of Pseudomonas aeruginosa isolated as being resistant to p-fluorophenylalanine (FPA-r) are pleiotropic, showing patterns of phenotypic alteration of host-controlled modification, growth rate at 37 and 43 °C, ability to grow on minimal medium, response to antibiotics and ribosomal characteristics. Alterations in host-controlled modification are also found in FPA-r mutants of Escherichia coli B.

The pleiotropy arising in these FPA-r mutants of P. aeruginosa appears to result from alterations in the specificity of protein synthesis. Phenotypic variations in host-controlled modification of the type found in the FPA-r mutants may provide a method for the detection of suppressor mutations which act by miscoding.

Type
Research Article
Information
Genetics Research , Volume 18 , Issue 2 , October 1971 , pp. 185 - 197
Copyright
Copyright © Cambridge University Press 1971

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