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Phenotypic expression of the fused (Fu) gene in chimaeric mice

Published online by Cambridge University Press:  14 April 2009

Olga E. Redina ,
Antonina I. Zhelezova ,
Alevtina N. Golubitsa ,
Alexander I. Agulnik  and
Anatoly O. Ruvinsky
Olga E. Redina*
Affiliation:
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia
Antonina I. Zhelezova
Affiliation:
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia
Alevtina N. Golubitsa
Affiliation:
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia
Alexander I. Agulnik
Affiliation:
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia
Anatoly O. Ruvinsky
Affiliation:
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia
*
*Corresponding author: Olga E. Redina, Institute of Cytology and Genetics, Lavrentjeva 10, Novosibirsk-90, 630090, Russia.
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Summary

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The dominant gene Fused (Fu) produces skeletal abnormalities during embryonic development. It was previously shown that C57BL/6 mice contain a suppressor of Fu, which acts after fertilization. Chimaeras were used to study whether this gene would suppress the Fu phenotype after the 8-cell stage of embryo development. We found no effect of the suppressor gene on Fu phenotype (its degree and frequency of expression) in chimaeric mice. We conclude that either the suppressor gene from C57BL/6 mice can only influence Fu expression at the intracellular level or Fu expression is determined before the 8-cell embryonic stage.

Type
Research Article
Information
Genetics Research , Volume 63 , Issue 3 , June 1994 , pp. 183 - 187
Copyright
Copyright © Cambridge University Press 1994

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