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Hybrid dysgenesis in Drosophila melanogaster: rules of inheritance of female sterility*

Published online by Cambridge University Press:  14 April 2009

William R. Engels
William R. Engels
Affiliation:
Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706
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Hybrid dysgenesis has been described as a syndrome of aberrant traits including sterility, male recombination, and mutation, which occurs in some inter-strain hybrids of Drosophila, but only from one of the two reciprocal crosses. In a series of experiments in which hybrids of various pedigrees were tested for sterility, it was found that a case of hybrid dysgenesis could be most easily interpreted as the interaction of two components. One component was found to be a polygenic Mendelian factor linked to each of the major chromosomes of π2, the paternally contributing strain (‘P strain’). These chromosomes were capable of causing sterility when inherited from either parent, provided the appropriate maternal component was also inherited. The ability to transmit this maternal component was designated ‘cytotype’ to indicate that it is a property of the entire cell. It was possible to classify nearly all hybrid females as either P or M cytotype on the basis of their ability to produce sterile daughters. All daughters of the M-cytotype mothers were susceptible to the sterilizing effects of the π2 chromosome, whereas all, or nearly all daughters of P-cytotype mothers were immune. When more than one of the π2 chromosomes were received by daughters of M-cytotype females, chromosomal interactions could be detected statistically, but the model of independent action remained a useful approximation. Cytotype was shown to be determined by chromosomal factors, but with limited cytoplasmic transmission. This unusual mode of inheritance can be compared with other cases of hybrid dysgenesis where the behaviour resembles that of self-replicating cytoplasmic particles which are dependent on certain chromosomes. The lack of sterility from intra-strain crosses can be explained by the fact that chromosomes capable of causing sterility also induce the P cytotype, and thus prevent sterility in the next generation.

Type
Research Article
Information
Genetics Research , Volume 33 , Issue 3 , June 1979 , pp. 219 - 236
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Bucheton, A. (1973). Contribution à l'étude de la stérilité femelle non mendélienne chez Drosophila melanogaster. Transmission héréditaire des degrés defficacité due facteur R. Comptes Rendus de l'Académie des Sciences de Paris D 276, 641–644.Google Scholar
Bucheton, A. & Picard, G. (1978). Non-mendelian female sterility in Drosophila melanogaster: hereditary transmission of reactivity levels. Heredity 40, 207–223.CrossRefGoogle Scholar
Colgan, D. J. & Angus, D. S. (1978). Bisexual hybrid sterility in Drosophila melanogaster. Genetics 89, 5–14.CrossRefGoogle ScholarPubMed
Engels, W. R. (1979). Germ line aberrations associated with a case of hybrid dysgenesis in Drosophila melanogaster males. Genetical Research. (In the Press.)CrossRefGoogle Scholar
Engels, W. R. & Preston, C. R. (1979). Hybrid dysgensis in Drosophila melanogaster: the biology of female and male sterility. Genetics. (In the Press.)CrossRefGoogle Scholar
Green, M. M. (1977). Genetic instability in Drosophila melanogaster: de novo induction of putative insertion mutations. Proceedings of the National Academy of Sciences of the U.S.A. 74, 3490–3493.CrossRefGoogle ScholarPubMed
Hayes, W. (1964). The Genetics of Bacteria and Their Viruses. New York: Wiley & Sons.Google Scholar
Hellack, J. J., Thompson, J. N. Jr, Woodruff, R. C. & Hisey, B. N. (1978). Male recombination and mosaics induced in Drosophila melanogaster by feeding. Experientia 34, 447.CrossRefGoogle Scholar
Kearsey, M. J., Williams, W. R., Allen, P. & Coulter, F. (1977). Polymorphism for chromosomes capable of inducing female sterility in Drosophila. Heredity 38(1), 109–115.CrossRefGoogle Scholar
Kidwell, M. G. (1979). Hybrid dysgenesis in Drosophila melanogaster: the relationship between the P-M and I-R interaction systems. Genetical Research (in the press).CrossRefGoogle Scholar
Kidwell, M. G. & Kidwell, J. F. (1976). Selection for male recombination in Drosophila melanogaster. Genetics 84, 333–351.CrossRefGoogle ScholarPubMed
Kidwell, M. G. & Novy, J. B. (1979). Hybrid dysgenesis in Drosophila melanogaster: sterility resulting from gonadal dysgenesis in the P–M system. Genetics (in the press.)CrossRefGoogle Scholar
Kidwell, M. G., Kidwell, J. F. & Ives, P. T. (1977). Spontaneous, non-reciprocal mutation and sterility in strain crosses of Drosophila melanogaster. Mutation Research 42, 89–98.CrossRefGoogle Scholar
Kidwell, M. G., Kidwell, J. F. & Sved, J. A. (1977). Hybrid dysgenesis in Drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility, and male recombination. Genetics, 86, 813–833.CrossRefGoogle ScholarPubMed
Lindsley, D. L. & Grell, E. H. (1968). Genetic variations of Drosophila melanogaster. Carnegie Institution of Washington, Publication No. 627.Google Scholar
Matthews, K. A., Slatko, B. E., Martin, D. W. & Hiraizumi, Y. (1978). A consideration of the negative correlation between transmission ratio and recombination frequency in a male recombination system in Drosophila melanogaster. Japanese Journal of Genetics 53, 13–25.Google Scholar
Picard, G. (1974). Contribution à l'étude d'un phénomène de stérilité a déterminisme non mendélien chez Drosophila melanogaster: Absence d'agents contagieux par contact. Comptes Rendus de l'Académie des Sciences de Paris D 278, 2561–2564.Google ScholarPubMed
Picard, G. (1976). Non-Mendelian female sterility in Drosophila melanogaster: hereditary transmission of I factor. Genetics 83, 107–123.CrossRefGoogle ScholarPubMed
Picard, G. (1978 a). Non-Mendelian female sterility in Drosophila melanogaster: sterility in the daughter progeny of SF and RSF females. Biologie Cellulaire 31, 235–244.Google Scholar
Picard, G. (1978 b). Non-Mendelian female sterility in Drosophila melanogaster: sterility in stocks derived from the genotypically inducer or reactive offspring of SF and RSF females. Biologie Cellulaire 31, 245–254.Google Scholar
Picard, G. & L'Heritier, Ph. (1971). A maternally inherited factor inducing sterility in Drosophila melanogaster. Drosophila Information Service 46, 54.Google Scholar
Picard, G. A., Bucheton, A., Lavige, A. J. & Pelisson, A. (1976). Répartition géographique des trois types de souches impliquées dans un phénomène de stéerilité à déterminisme non mendelien chez Drosophila melanogaster. Comptes Rendus de l'Académie des Sciences de Paris D 282, 1813–1816.Google ScholarPubMed
Schaefer, R. E., Kidwell, M. G. & Fausto-Sterling, A. (1979). Hybrid dysgenesis in Drosophila melanogaster: morphological and cytological studies of ovarian dysgenesis. Genetics (in the press).CrossRefGoogle Scholar
Slatko, B. E. (1978). Evidence for newly induced genetic activity responsible for male recombination induction in Drosophila melanogaster. Genetics 90, 105–124.CrossRefGoogle ScholarPubMed
Sochacka, J. H. M. & Woodruff, R. C. (1976). Induction of male recombination in Drosophila melanogaster by injection of extracts of flies showing male recombination. Nature, 262, 287–289.CrossRefGoogle ScholarPubMed
Sved, J. A. (1976). Hybrid dysgenesis in Drosophila melanogaster: a possible explanation in terms of spatial organization of chromosomes. Australian Journal of Biological Sciences 29, 375–388.CrossRefGoogle ScholarPubMed
Sved, J. A., Murray, D. C., Schaefer, R. E. & Kidwell, M. G. (1978). Male recombination is not induced in Drosophila melanogaster by extracts of strains with male recombination potential. Nature 275, 457–458.CrossRefGoogle Scholar
Thompson, J. N. Jr. & Woodruff, R. C. (1978). Mutator genes: pacemakers of evolution. Nature. (In the Press.)CrossRefGoogle Scholar
Waddle, F. R. & Oster, I. I. (1974). Autosomal recombination in males of Drosophila melanogaster caused by a transmissible factor. Journal of Genetics 61, 177–183.CrossRefGoogle Scholar
Woodruff, R. C. & Thompson, J. N. (1977). An analysis of spontaneous recombination in Drosophila melanogaster males. Heredity 38, 291–307.CrossRefGoogle Scholar
Yannopoulos, G. (1978). Studies on male recombination in a Southern Greek Drosophila melanogaster population, (c) Chromosomal abnormalities at male meiosis. (d) Cytoplasmic factor responsible for the reciprocal cross effect. Genetical Research 31, 187–196.CrossRefGoogle Scholar