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Genetics of plasma transferrins in the mouse

Published online by Cambridge University Press:  14 April 2009

B. L. Cohen
B. L. Cohen
Affiliation:
Institute of Animal Genetics, University of Edinburgh
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1. The plasma proteins of six inbred strains of mice have been studied, using starch-gel electrophoresis.

2. The existence of two alternative plasma transferrin (β-globulin) phenotypes has been demonstrated. Five of the strains have one of these and one strain has the other. Each of the two transferrin patterns comprises three (or possibly only two) electrophoretic bands. The two patterns differ in all of these bands.

3. The two transferrin types recognized are determined by a pair of allelic, autosomal genes (designated TrfA and TrfB). The TrfA phenotype (CBA strain) is determined by the genotype TrfA/TrfA, and the TrfB phenotype (A, C57BL, JU, KL, RIII strains) by the genotype TrfB/TrfB. The phenotype TrfAB, of the heterozygote (genotype TrfA/TrfB), is distinguishable and shows four (or possibly only three) bands. In this way it closely resembles a mixture of equal parts of TrfA and TrfB plasma.

4. No linkage was detected between the Trf locus and sex, the agouti locus or the haemoglobin locus.

5. The possible molecular basis of the action of the transferrin alleles in the mouse, and the widespread distribution in mammals of polymorphism involving the transferrins, are discussed.

Type
Research Article
Information
Genetics Research , Volume 1 , Issue 3 , November 1960 , pp. 431 - 438
Copyright
Copyright © Cambridge University Press 1960

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