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The genetic sensitivity to X-rays of mouse foetal gonads

Published online by Cambridge University Press:  14 April 2009

T. C. Carter
Affiliation:
Medical Research Council Radiobiological Research Unit, Harwell, Berkshire, England
Mary F. Lyon
Affiliation:
Medical Research Council Radiobiological Research Unit, Harwell, Berkshire, England
Rita J. S. Phillips
Affiliation:
Medical Research Council Radiobiological Research Unit, Harwell, Berkshire, England

Extract

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The mutation rate at seven specific loci was measured among the offspring of male and female mice exposed as 17½-day-old foetuses to 200 r. X-rays. In the female series the mutation rate was lower, by a factor of about four, than the comparable adult rate; in the male series the mutation rate was lower but not statistically significantly lower than in adults.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1960

References

REFERENCES

Brambell, F. W. R. (1927). The development and morphology of the gonads of the mouse. Part I. The morphogenesis of the indifferent gonad and the ovary. Proc. roy. Soc. B, 101, 391409.Google Scholar
Carter, T. C. (1958). Radiation-induced gene mutation in adult female and foetal male mice. Brit. J. Radiol. 31, 407411.Google Scholar
Carter, T. C., Lyon, M. F. & Phillips, R. J. S. (1958). Genetic hazard of ionising radiations. Nature, Lond., 182, 409.Google Scholar
Fisher, R. A. & Yates, F. (1953). Statistical Tables for Biological, Agricultural and Medical Research, 4th ed.Edinburgh: Oliver and Boyd.Google Scholar
Kimball, A. W. (1956). Approximate confidence intervals for specific locus mutation rates. Amer. Nat. 90, 369376.Google Scholar
Maximow, A. A. & Bloom, W. (1952). A Textbook of Histology, 6th ed.Philadelphia: W. B. Saunders Co.Google Scholar
Medical Research Council (1956). The Hazards to Man of Nuclear and Allied Radiations. London: H.M.S.O.Google Scholar
Otis, E. M. & Brent, R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. 120, 3364.Google Scholar
Phillips, R. J. S. (1960). A comparison of mutation induced by acute X- and chronic γ-irradiation in mice. In the press.Google Scholar
Rugh, R. & Jackson, S. (1958). Effect of fetal X-irradiation upon the subsequent fertility of the offspring. J. exp. Zool. 138, 209221.Google Scholar
Russell, W. L., Bangham, J. W. & Gower, J. S. (1958). Comparison between mutations induced in spermatogonial and post-spermatogonial stages in the mouse. Proc. 10th int. Congr. Genet. 2, 245246.Google Scholar
Russell, W. L., Russell, L. B. & Cupp, M. B. (1959). Dependence of mutation frequency on radiation dose rate in female mice. Proc. nat. Acad. Sci., Wash., 45, 1823.CrossRefGoogle ScholarPubMed
Russell, W. L., Russell, L. B., & Kelly, E. M. (1958). Radiation dose rate and mutation frequency. Science, 128, 15461550.CrossRefGoogle ScholarPubMed