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Performance on verbal fluency in late-onset schizophrenia is more preserved than in early-onset schizophrenia

Published online by Cambridge University Press:  13 August 2021

E. Abdullina ,
G. Rupchev ,
M. Savina ,
Y. Panikratova ,
E. Kucherova ,
V. Sheshenin  and
M. Morozova
E. Abdullina*
Affiliation:
Department Of Gerontological Psychiatry, FSBSI Mental Health Research Center, Moscow, Russian Federation
G. Rupchev
Affiliation:
Laboratory Of Psychopharmacology, FSBSI Mental Health Research Center, Moscow, Russian Federation
M. Savina
Affiliation:
Department Of Gerontological Psychiatry, FSBSI Mental Health Research Center, Moscow, Russian Federation
Y. Panikratova
Affiliation:
Laboratory Of Neuroimaging And Multimodal Analysis, FSBSI Mental Health Research Center, Moscow, Russian Federation
E. Kucherova
Affiliation:
Laboratory Of Psychopharmacology, FSBSI Mental Health Research Center, Moscow, Russian Federation
V. Sheshenin
Affiliation:
Department Of Gerontological Psychiatry, FSBSI Mental Health Research Center, Moscow, Russian Federation
M. Morozova
Affiliation:
Laboratory Of Psychopharmacology, FSBSI Mental Health Research Center, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

According to the literature, cognition may be more preserved in late-onset schizophrenia (LOS) compared to early-onset schizophrenia (EOS), but data are limited.

Objectives

To compare performance on cognitive tests in LOS and EOS.

Methods

LOS patients (n=14, mean age 58.1±8.2, 13 females, illness duration 1.07±1.5 years) and age-comparable controls (n=17, mean age 55.3±7.8, 12 females), EOS patients (n=25, mean age 20.7±3.9, 25 males, illness duration 0.75±0.62 years) and age-comparable controls (n=15, mean age 22.9±2.3, 15 males) underwent the Brief Assessment of Cognition in Schizophrenia (BACS) comprised of six subtests: Verbal Memory, Digit Sequencing, Verbal Fluency, Token Motor Task, Symbol Coding, and Tower of London. The Mann-Whitney U test with Bonferroni correction for multiple comparisons was applied (p <.05/8, i.e. p <.006).

Results

Compared to LOS, EOS patients had lower score on Verbal Fluency (VF): U=78, p=.004; mean T-scores are 43.5±9.5 and 33.6±12.6 for LOS and EOS, respectively. Additionally, we compared VF performance in each clinical group with age-comparable controls and revealed significantly lower performance in both LOS (U=37.5, p=.001) and EOS (U=56.5, p=.000).

Conclusions

Performance on VF is deteriorated in clinical groups, but may be more intact in LOS compared to EOS. This result is of particular interest because low performance on VF is considered as a cognitive endophenotype of schizophrenia. Performance on VF requires preserved executive functions, language, and processing speed. Our results are in line with the idea that LOS and EOS may be different subtypes of schizophrenia. Limitation of this study is that the clinical groups are not sex-matched.

Keywords

verbal fluencylate-onset schizophreniacognition
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S528
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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