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P-1200 - Role of Cognitive Reserve on Severity of Illness in Psychosis: a Longitudinal Study

Published online by Cambridge University Press:  15 April 2020

M. Alonso Pinedo ,
A. García Guerrero ,
N. Ojeda del Pozo ,
J. García Ormaza ,
J. Peña Lasa ,
R. Segarra Echevarría ,
A. Ugarte Ugarte ,
L. Martín Otaño ,
Y. Ballorca Arnáiz  and
M. Gutierrez Fraile
M. Alonso Pinedo
Affiliation:
Department of Psychiatry, Osakidetza, Donosti Hospital, San Sebastian, Spain CIBERSAM, Bilbao, Spain
A. García Guerrero
Affiliation:
CIBERSAM, Bilbao, Spain
N. Ojeda del Pozo
Affiliation:
CIBERSAM, Bilbao, Spain
J. García Ormaza
Affiliation:
Faculty of Psychology and Education, University of Deusto, Bilbao, Spain
J. Peña Lasa
Affiliation:
CIBERSAM, Bilbao, Spain
R. Segarra Echevarría
Affiliation:
CIBERSAM, Bilbao, Spain Faculty of Psychology and Education, University of Deusto, Bilbao, Spain
A. Ugarte Ugarte
Affiliation:
CIBERSAM, Bilbao, Spain Department of Psychiatry, Osakidetza, Cruces Hospital, Barakaldo, Spain
L. Martín Otaño
Affiliation:
Department of Psychiatry, Osakidetza, Donosti Hospital, San Sebastian, Spain
Y. Ballorca Arnáiz
Affiliation:
Department of Psychiatry, Osakidetza, Donosti Hospital, San Sebastian, Spain
M. Gutierrez Fraile
Affiliation:
CIBERSAM, Bilbao, Spain Department of Psychiatry, Osakidetza, Cruces Hospital, Barakaldo, Spain Department of Psychiatry, Osakidetza, Santiago Apostol Hospital, Vitoria, Spain

Abstract

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Objectives

The objective of the present study was to examine the predictive value of clinical and cognitive -including the cognitive reserve (CR) - variables on the severity of the patient's illness at one year of follow-up.

Methods

A study was held with 45 patients with first episode psychosis (FEP) from 3 main hospitals in the Basque Country (Spain). All patients underwent cognitive, clinical, and functional assessments at baseline and at 6 months follow-up. The cognitive measures included were: the Stroop test, Vocabulary sub-test from WAIS-III, the WCST, and Trail Making Test. The clinical and functional measures included were: Positive and Negative Syndrome Scale (PANSS), Young Mania Scale, Montgomery-Asberg Depression scale, and CGI (Clinical Global Impression).

Results

Six-months follow-up data were available for 29 patients. Regression analysis was performed with the 6-month follow-up CGI measure as a dependent variable. Results showed that after controlling for CGI at baseline, -PANSS Negative Symptoms Scale (B = 0.47, p ≤ .05) and the CR measure -Vocabulary from WAIS-III- (B = 0.36, p ≤ .05) were the only two which significantly predicted severity of illness after 6 months (R2 = 0.44) and remained significant when CGI at base line was controlled in the regression analysis. The rest variables did not reach statistical significance.

Conclusions

These findings emphasize that CR have a role on outcome in first episode psychosis, and enhance that exist a relation between cognition and clinical measures in psychosis.

Funding

Basque Government, Health Department (2008111010); EITB-Maratoia (BIO 09/EM/015).

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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