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P02-297 - Neurocognitive Functioning in Untreated Patients with Bulimia Nervosa: Neuroendocrine, Personality and Clinical Correlates

Published online by Cambridge University Press:  17 April 2020

P. Bucci ,
S. Galderisi ,
A. Mucci ,
L. Bellodi ,
G.B. Cassano ,
P. Santonastaso ,
S. Erzegovesi ,
A. Favaro ,
M. Mauri  and
E. Tenconi
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P. Bucci
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
S. Galderisi
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
A. Mucci
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
L. Bellodi
Affiliation:
Department of Neuropsychiatric Sciences, Vita-Salute University, Istituto Scientifico HS Raffaele, Milan, Italy
G.B. Cassano
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy
P. Santonastaso
Affiliation:
Department of Neurosciences, University of Padua, Padua, Italy
S. Erzegovesi
Affiliation:
Department of Neuropsychiatric Sciences, Vita-Salute University, Istituto Scientifico HS Raffaele, Milan, Italy
A. Favaro
Affiliation:
Department of Neurosciences, University of Padua, Padua, Italy
M. Mauri
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy
E. Tenconi
Affiliation:
Department of Neurosciences, University of Padua, Padua, Italy
P. Monteleone
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
M. Maj
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy

Abstract

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Objectives

Cognitive impairment in patients with eating disorders was reported by the majority of studies addressing this issue. However, heterogeneous patterns of cognitive dysfunctions were observed and, in a minority of studies, no impairment was found. The present study was aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and to demonstrate that neuroendocrine, personality and clinical characteristics influence neurocognitive performance in BN.

Methods

Attention, executive control, conditional and incidental learning were evaluated in 83 untreated female patients with BN and 77 healthy controls. Cortisol and 17β-estradiol plasma levels were assessed. Cloninger's Temperament and Character Inventory-Revised (TCI-R), the Eating Disorder Inventory-2 and the Montgomery-Asberg Depression Rating Scale were administered.

Results

No impairment of cognitive performance was found in subjects with BN vs. healthy controls. The higher the cortisol level and “Self-directedness” scores the better the performance on conditional learning, while 17β-estradiol levels showed an opposite pattern of association; “Reward dependence” scores were associated to a worse performance on incidental learning; depressive symptomatology negatively influenced the performance on the WCST.

Conclusions

No cognitive impairment was found in untreated patients with BN in the explored cognitive domains. An influence of neuroendocrine, personality and clinical variables on neurocognitive functioning was found, which might explain discrepancies in literature findings.

Type
Psychosomatic disorders / Eating disorders / Somatoform disorders
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E996
Copyright
Copyright © European Psychiatric Association 2010
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