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Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature

Published online by Cambridge University Press:  01 September 2022

A. Esagoff ,
D. Stevens ,
M. Bray ,
B. Bryant ,
N. Daneshvari ,
D. Jung ,
C. Rodriguez ,
L. Richey ,
L. Luna  and
H. Sair
...Show all authors
A. Esagoff*
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
D. Stevens
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
M. Bray
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
B. Bryant
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
N. Daneshvari
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
D. Jung
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
C. Rodriguez
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
L. Richey
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
L. Luna
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
H. Sair
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
M. Peters
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
*
*Corresponding author.

Abstract

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Introduction

Neuroimaging has been a highly utilized technique for studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) independently of one another, however, neuroimaging has increasingly been identified as a useful tool in better understanding TBI-related psychiatric conditions, such as PTSD.

Objectives

To complete a systematic review of the literature examining neuroimaging findings in TBI-related PTSD and to highlight the current literature’s limitations in order to strengthen future research.

Methods

A PRISMA compliant literature search was conducted in PubMed (MEDLINE), PsychINFO, EMBASE, and Scopus databases prior to May of 2019. The initial database query yielded 4388 unique articles, which were narrowed down based on specified inclusion criteria (e.g., clear TBI definition, clinician-diagnosed PTSD, statistically analyzed relationship between neuroimaging and PTSD, quantified time interval between TBI and neuroimaging).

Results

A final cohort of 10 articles met inclusion criteria, comprising the findings of 482 participants with TBI. Key neuroanatomical findings among the included articles suggest that PTSD is associated with significant changes in whole-brain networks of resting state connectivity and disruptions in bilateral frontal and temporal white matter tracts, fronto-limbic pathways, the internal capsule, and the uncinate fasciculus (Figure 1).Figure 1a:

Neuroimaging Findings in TBI-related PTSD.

Figure 1b.

Replicated Neuroimaging Findings in TBI-related PTSD in the Right Uncinate Fasciculus.

Conclusions

Additional inquiry with attention to specified imaging timing post-injury, consistent TBI definitions, clinician-diagnosed TBI and PTSD, and control groups is crucial to extrapolating discrepancies between primary and TBI-related PTSD. Prospective studies could further differentiate predisposing factors from sequelae of TBI-related PTSD.

Disclosure

No significant relationships.

Keywords

NeuroimagingPost-traumatic stress disordertraumatic brain injury
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S471 - S472
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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