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Infertility Among Male Patients With Tramadol abuse

Published online by Cambridge University Press:  19 July 2023

A. W. Abouhendy ,
M. M. Bassiony ,
U. M. Youssef  and
H. M. Elgohary
A. W. Abouhendy*
Affiliation:
Addiction Unit, Psychological Medicine Hospital, Cairo
M. M. Bassiony
Affiliation:
Addiction Unit, Zagazig university, Zagazig, Egypt
U. M. Youssef
Affiliation:
Addiction Unit, Zagazig university, Zagazig, Egypt
H. M. Elgohary
Affiliation:
Addiction Unit, Zagazig university, Zagazig, Egypt
*
*Corresponding author.

Abstract

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Introduction

Tramadol abuse has become a crisis in Egypt and many other Middle Eastern countries. Tramadol abuse is associated with sexual dysfunction and male infertility, according to recent animal and human studies.

Objectives

The objective of this study was to compare tramadol abuse patients and healthy controls regarding free testosterone and prolac-tin levels and semen analysis.

Methods

Sixty patients with opiate use disorders attributed to tramadol (OUD-T) based on Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) diagnostic criteria and 30 healthy controls were included in the study. Sociodemographic and clinical data and urine, blood, and semen samples were collected from patients and controls for assessment.

Results

Compared with controls, OUD-T patients had higher prolactin and lower free testosterone levels. Patients with OUD-T were more likely to have lower sperm count and higher abnormal motility and forms of sperms compared with controls.

Conclusions

Patients with OUD-T were found to be more likely to have lower free testosterone levels and lower sperm counts and vitality, and higher prolactin levels and sperm abnormal forms compared with controls.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S59
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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