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The impact of depression in Alzheimer’s disease hospitalized patients: a study protocol for a nationwide retrospective study

Published online by Cambridge University Press:  01 September 2022

B. Brás ,
A.R. Ferreira ,
M. Gonçalves-Pinho ,
A. Freitas  and
L. Fernandes
B. Brás*
Affiliation:
University of Porto, Faculty Of Medicine, Porto, Portugal
A.R. Ferreira
Affiliation:
University of Porto, Faculty Of Medicine, Porto, Portugal Faculty of Medicine, University of Porto, Department Of Clinical Neurosciences And Mental Health, Porto, Portugal Faculty of Medicine, University of Porto, Cintesis – Center For Health Technology And Services Research, Porto, Portugal
M. Gonçalves-Pinho
Affiliation:
Faculty of Medicine, University of Porto, Cintesis – Center For Health Technology And Services Research, Porto, Portugal Faculty of Medicine, University of Porto, Department Of Community Medicine, Information And Health Decision Sciences (medcids), Porto, Portugal Centro Hospitalar do Tâmega e Sousa, Department Of Psychiatry And Mental Health, Penafiel, Portugal
A. Freitas
Affiliation:
Faculty of Medicine, University of Porto, Cintesis – Center For Health Technology And Services Research, Porto, Portugal Faculty of Medicine, University of Porto, Department Of Community Medicine, Information And Health Decision Sciences (medcids), Porto, Portugal
L. Fernandes
Affiliation:
Faculty of Medicine, University of Porto, Department Of Clinical Neurosciences And Mental Health, Porto, Portugal Faculty of Medicine, University of Porto, Cintesis – Center For Health Technology And Services Research, Porto, Portugal Psychiatry Service, Centro Hospitalar Universitário De São João, Porto, Portugal
*
*Corresponding author.

Abstract

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Introduction

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. About 40-50% of AD patients are also affected by depression, with mounting evidence suggesting its association with worse disease prognosis and negative outcomes, such as lower quality of life, higher mortality and more hospitalizations. However, few studies have specifically measured the association of depression with AD hospitalization outcomes.

Objectives

To characterize depression among all hospitalizations with a registered diagnosis of AD and to explore its association with hospitalization outcomes, including in-hospital mortality, length of stay and discharge destination.

Methods

A retrospective observational study will be conducted following the RECORD statement. A Portuguese nationwide hospitalization database from all mainland public hospitals will be used. Episodes of inpatients ≥65 years old with a primary or secondary diagnosis of AD (ICD-9-CM code 331.0), discharged between 2008-2015, will be selected. Codes 296.2X, 296.3X, 300.4 and 311 will be used to identify episodes with a concomitant registry of depression at any diagnostic position. Descriptive, univariate and multivariate approaches will be used.

Results

A total of 61 361 episodes complying with the fixed criteria will be assigned to one of two groups (with vs without depression). Groups will be compared regarding sociodemographic characteristics, comorbidity profile, type of admission (planned vs urgent) and hospitalization outcomes. Results regarding the association of depression and outcomes will be presented as crude and adjusted odds ratios (OR).

Conclusions

With this nationwide analysis, we expect to contribute to the clarification of depression impact on AD hospitalizations, so that best-practice care may be provided to these patients.

Disclosure

No significant relationships.

Keywords

Alzheimer’s diseaseDepressionAdministrative DatabaseHospitalization outcomes
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S260 - S261
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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