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Effects of negative autobiographical memories retrieval on corticospinal excitability and sensorimotor integration

Published online by Cambridge University Press:  23 March 2020

L. Mineo ,
C. Concerto ,
D. Patel ,
T. Myorga ,
D. Coira ,
E. Chusid ,
E. Aguglia  and
F. Battaglia
L. Mineo
Affiliation:
Seton Hall University, Health and medical sciences, South Orange, USA
C. Concerto
Affiliation:
Clinical and experimental medicine, Psychiatry Unit, Catania, Italy
D. Patel
Affiliation:
New York College of Podiatric Medicine, Preclinical Sciences, NY, USA
T. Myorga
Affiliation:
New York College of Podiatric Medicine, Preclinical Sciences, NY, USA
D. Coira
Affiliation:
Hackensack University Medical Center, Psychiatry and Behavioral Medicine, Hackensack, NJ, USA
E. Chusid
Affiliation:
New York College of Podiatric Medicine, Preclinical Sciences, NY, USA
E. Aguglia
Affiliation:
Clinical and experimental medicine, Psychiatry Unit, Catania, Italy
F. Battaglia*
Affiliation:
Seton Hall University, Health and medical sciences, South Orange, USA
*
* Corresponding author.

Abstract

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Introduction

Previous transcranial magnetic stimulation (TMS) studies indicate that exposing the subjects to an emotionally valent stimulus results in larger motor evoked potentials (MEP). Up to date, no TMS studies have been conducted in order to investigate the effect of personal memories with emotional value on corticospinal excitability.

Objects

To investigate changes in corticospinal excitability and sensorimotor integration induced by retrieval of negative or neutral autobiographical memories (AM).

Aims

To contribute to a further characterization of neural circuits involved during the evocation of negative AM.

Methods

In 12 healthy volunteers, we recorded motor evoked potentials (MEPs) elicited by TMS pulses during the retrieval of negative AM or neutral AM. Furthermore, we also tested Short-interval Intracortical Inhibition (SICI), Intracortical facilitation (ICF), Short and Long afferent Inhibition (SAI and LAI) in the two different experimental conditions.

Results

Retrieval of negative AM induced a larger increase in MEP amplitude (35.01%) compared to neutral AM (F(1,22) = 7.04, P = 0.013). Furthermore we showed that retrieval of Negative AM increasedn ICF (F(1,22) = 5, P = 0.03) and decrease SAI (F(1,22) = 7.04, P = 0.039). The other TMS parameters were different between conditions.

Conclusions

Our results indicate that evocation of negative AM induce a complex modulation of excitatory and inhibitory sensorimotor networks. Further studies are needed to explore the link of these electrophysiological biomarkers with the strength, valence and specificity of negative AM.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW105
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S138
Copyright
Copyright © European Psychiatric Association 2016
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