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Cortical dysfunction and schizophrenic deficit. Preliminary findings with the delayed reaction paradigm

Published online by Cambridge University Press:  16 April 2020

A Partiot ,
R Jouvent ,
B Dubois ,
M Verin ,
M Montreuil ,
Y Agid  and
D Widlocher
A Partiot
Affiliation:
Inserm U302 (groupe COGNEM) Psychopathologie et psychopharmacologie des comportements, Pavillon Clérambault
R Jouvent
Affiliation:
Inserm U302 (groupe COGNEM) Psychopathologie et psychopharmacologie des comportements, Pavillon Clérambault
B Dubois
Affiliation:
Inserm U289 Médecine Expérimentale, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, Paris, France
M Verin
Affiliation:
Inserm U289 Médecine Expérimentale, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, Paris, France
M Montreuil
Affiliation:
Inserm U302 (groupe COGNEM) Psychopathologie et psychopharmacologie des comportements, Pavillon Clérambault
Y Agid
Affiliation:
Inserm U289 Médecine Expérimentale, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, Paris, France
D Widlocher
Affiliation:
Inserm U302 (groupe COGNEM) Psychopathologie et psychopharmacologie des comportements, Pavillon Clérambault
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Summary

Performance of patients with schizophrenia (n = 15) was compared to that of patients with vascular ischemic lesions of the dorsolateral prefrontal cortex (n= 10) and to age-matched controls (n= 15) in delayed reaction tasks known to be specific markers of the functions of the frontal lobe. The performance of patients with schizophrenia was similar to that of patients with prefrontal lesions in the delayed response task (DR) and the spatial discrimination-reversal task (SD and RV) but not in the delayed alternation task (DA) in which they performed as well as controls. The behavioural profile of responses in delayed reaction tasks for the schizophrenic patients was identical to that of patients with basal ganglia lesions reported in a previous study. These results suggest that in some patients with schizophrenia, a frontal lobe deficit could be indirectly induced by a dysfunction of the basal ganglia. This problem could be due either to the pathological process itself or to the effect of the neuroleptic treatment.

Keywords

schizophreniafrontal lobedelayed reaction tasknegative symptomdopamine pathway
Type
Original article
Information
European Psychiatry , Volume 7 , Issue 4 , 1992 , pp. 171 - 175
Copyright
Copyright © Elsevier, Paris 1992

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorder, Third ed revised (DSM lll-R). Washington DCGoogle Scholar
Benes, FMDavidson, JBird, ED (1986) Cytoarchitectural studies of cerebral cortex of schizophrenics. Arch Gen Psychiatry 43, 31–35CrossRefGoogle ScholarPubMed
Brozovski, TJBrown, RMRosvold, HEGoldman, PS (1979) Cognitive deficit caused by regional depletion of DA in prefrontal cortex of rhesus monkey. Science 205, 929–931CrossRefGoogle Scholar
Dubois, BVerin, MPartiot, AAgid, Y (1991) Delayed reaction study in patients with frontal lobe lesions. Meeting of American Academy of Neurology, BostonGoogle Scholar
Glowinski, JTassin, JPThierry, AM (1984) The mesocortico-prefrontal dopaminergic neurons. Trends Neuro Sci, 415–418CrossRefGoogle Scholar
Goldberg, TEWeinberger, DRBerman, KFPliskin, NPlodd, M (1987) Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test. Arch Gen Psychiatry 44, 1008–1014CrossRefGoogle ScholarPubMed
Goldberg, TEWeinberger, DR (1988) Probing prefrontal function in schizophrenia with neuropsychological paradigms. Schizophr Bull 14, 179–183CrossRefGoogle ScholarPubMed
Gray, JAFeldon, JRawlins, JNPHemsley, DRSmith, AD (1991) The neuropsychology of schizophrenia. Behav Brain Sci 14, 1–84CrossRefGoogle Scholar
Jacobsen, CF (1936) Study of cerebral function in primates. Comp Psychol Monogr 13, 1–68Google Scholar
Le Moal, MSimon, H (1991) Mesocorticolimbic dopaminergic network: functional and regulatory roles. Physiol Rev 71, 155–234CrossRefGoogle ScholarPubMed
Levin, S (1984) Frontal lobe dysfunction in schizophrenia. II. Impairments of psychological and brain functions. J Psychiatr Res 18, 57–72CrossRefGoogle ScholarPubMed
Levin, SYurgelun-Todd, DCraft, S (1989) Contributions of clinical neuropsychology to the study of schizophrenia. J Abnorm Psychol 98, 341–356CrossRefGoogle Scholar
Pribram, KHAhumada, AHartog, JRoss, L (1964) A progress report on the neurological processes disturbed by frontal lesions in primates. In: The Frontal Granular Cortex and Behavior (Warren, JMAkert, K eds) Mac Graw-Hill, New York, 28–55Google Scholar
Rosenkilde, CE (1983) Functions of the prefrontal cortex. Acta Physiol Scand (suppl) 514, 1–58Google ScholarPubMed
Seidman, LJ (1983) Schizophrenia and brain dysfunction. An integration of recent neurodiagnostic findings. Psychol Bull 94, 195–238CrossRefGoogle ScholarPubMed
Shelton, CSKarson, CNDoran, ARPickard, DBigelow, LBWeinberger, DR (1988) Cerebral structural pathology in schizophrenia: evidence of a selective prefrontal cortical defect. Am J Psychiatry 145, 154–163Google ScholarPubMed
Simon, HScatton, BLe Moal, M (1980) Dopaminergic A10 neurones are involved in cognitive functions. Nature (Lond) 286, 150–151CrossRefGoogle ScholarPubMed
Verin, MPartiot, APillon, BDubois, BAgid, Y (1991) Study of delayed reaction in patients with basal ganglia lesions. 10th International Symposium on Parkinson's disease, TokyoGoogle Scholar
Weinberger, DR (1988) Schizophrenia and frontal lobe. Trends Neurosci 11, 367–370CrossRefGoogle ScholarPubMed
Yurgelun-Todd, DLevin, S (1988) Problem of attention in schizophrenia. In: Experimental Approach of Psychopathology (Kietzman, MLSutton, SZubin, J eds) Academic Press, New York, 139–166Google Scholar
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