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Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms

Published online by Cambridge University Press:  01 September 2022

D. Khalifa ,
L. Rashed ,
A. Shamseldeen  and
S. Stephan
D. Khalifa*
Affiliation:
Kasr Al Ainy hospitals, Cairo University, Psychiatry, Cairo, Egypt
L. Rashed
Affiliation:
Kasr Al Ainy hospitals, Cairo University, Biochemistry, Cairo, Egypt
A. Shamseldeen
Affiliation:
Kasr Al Ainy hospitals, Cairo University, Physilogy, Cairo, Egypt
S. Stephan
Affiliation:
Kasr Al Ainy hospitals, Cairo University, Physilogy, Cairo, Egypt
*
*Corresponding author.

Abstract

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Introduction

Identifying a feasible model of chronic schizophrenia would be valuable for studying the possible underlying mechanism and to investigate emerging treatments. Our hypothesis starts from the observation that combining ketamine with isolation could result in long-lasting neuro-psychological deficits and schizophrenia-like features; thus, it could probably be used as the first model of chronic schizophrenia that emphasizes the characteristic of having a multifactorial etiology

Objectives

creation of a complex animal model capable of exhibiting the multifactorial origin and manifestation of schizophrenia.

Methods

we investigated the effects of ketamine administration combined with isolation in inducing schizophrenia-like symptoms in male albino rats and the brain reactive oxygen species levels.

Results

Our results showed that the number of lines crossings in the open field test, the number of open arm entries in the elevated plus maze, and the spontaneous alternations percentage in the Y-maze were significantly lower in the ketamine + isolation group compared to both the control and ketamine + social housing group (p < 0.05). Furthermore, the ketamine + isolation intervention significantly increased the MDA levels and decreased the GPx levels both in the hippocampus and the cortex of the rats. In addition, our premise of creating a model capable of exhibiting both positive and negative symptoms of schizophrenia was also based on adding the aripiprazole treatment to a group of rats

Conclusions

combining ketamine with isolation could result in long-lasting neuro-psychological deficits and schizophrenia-like features

Disclosure

No significant relationships.

Keywords

ModelKetamineschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S192
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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