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Synaptic plasticity and tianeptine: structural regulation

Published online by Cambridge University Press:  16 April 2020

E. Fuchs ,
B. Czéh ,
T. Michaelis ,
G. de Biurrun ,
T. Watanabe  and
J. Frahm
E. Fuchs*
Affiliation:
Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077Göttingen, Germany
B. Czéh
Affiliation:
Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077Göttingen, Germany
T. Michaelis
Affiliation:
Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, 37070Göttingen, Germany
G. de Biurrun
Affiliation:
Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077Göttingen, Germany
T. Watanabe
Affiliation:
Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, 37070Göttingen, Germany
J. Frahm
Affiliation:
Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, 37070Göttingen, Germany
*
*Corresponding author. E-mail address: [email protected] (E. Fuchs).
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Summary

Stress-induced structural and cellular alterations in the hippocampus can contribute to the pathophysiology of depression. The reversal of these alterations may be a mechanism by which antidepressants achieve their therapeutic effect. The aim of the present study was therefore to investigate  the effect of tianeptine on stress-induced structural changes and alterations in cerebral metabolites. To this end, psychosocially stressed male tree shrews were treated with tianeptine. A combination of in vivo and postmortem methods was used to evaluate the antidepressant treatment on the preservation of neuronal plasticity. It was found that all stress-induced effects were prevented by the administration of tianeptine. It is concluded that these findings provide experimental evidence for recent theories that impairment of neuronal viability and neuroplasticity might be important causal factors in mood disorders, suggesting tianeptine as a potential stimulator of neural resilience.

Keywords

DepressionHippocampusStressTianeptine
Type
Research Article
Information
European Psychiatry , Volume 17 , Issue S3: A new pharmacology of depression: the concept of synaptic plasticity , July 2002 , pp. 311s - 317s
Copyright
Copyright Éditions scientifiques et médicales Elsevier SAS 2002

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Footnotes

To be presented at ECNP Barcelona, 5-9 October 2002, during the symposium “A new pharmacology of depression: the concept of synaptic plasticity.”

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