Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-24T06:23:00.836Z Has data issue: false hasContentIssue false
  • English
  • Français

Combining nefazodone and midazolam during ECT

Published online by Cambridge University Press:  16 April 2020

A. Conca ,
Z. Al-Dubai ,
P. König  and
W. Beraus
A. Conca
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
Z. Al-Dubai
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
P. König
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
W. Beraus
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
Get access

Summary

We report the case of a patient suffering from dysthymia. He underwent successful ECT treatment and was medicated with nefazodone and midazolam. Comparing the EEG and motor seizure duration in the periods with and without midazolam, no significant differences were recorded, but the dosage of thiopental and of succinylcholine had to be increased markedly after midazolam was discontinued (P < 0.05; ANOVA). This case indicates a substantial pharmacodynamic interaction between nefazodone, midazolam, thiopental, and succinylcholine.

Keywords

ETCmidazolamnefazodone
Type
Case report
Information
European Psychiatry , Volume 14 , Issue 6 , October 1999 , pp. 360 - 362
Copyright
Copyright © European Psychiatric Association 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association. The practice of ECT: recommendations for treatment, training, and privileging. Task force report on ECT Washington, DC: American Psychiatric Press; 1990.Google Scholar
Coffey, CELucke, JWeiner, RDKrystal, ADAque, M. Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold Biol Psychiatry 1995 ; 37: 713-20.CrossRefGoogle ScholarPubMed
Gassy, JERay, JM. A survey of ECT in a general hospital psychiatric unit Aust NZ J Psychiatry 1990 ; 24: 385-90.CrossRefGoogle Scholar
Greenberg, RMPettinati, HMBenzodiazepine and electroconvulsive therapy Convulsive Ther 1993 ; 9: 262-73.Google ScholarPubMed
Kellner, CHBourgon, LN. Combining ECT and antidepressants: time to reassess J Ect 1998 ; 14 : 65-7.CrossRefGoogle ScholarPubMed
Linder, MWRussell, APrough, AValdes, R Jr. Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency Clin Chem 1997 ; 43 : 254-66.CrossRefGoogle ScholarPubMed
Nemeroff, CBdeVane, CLPollock, BG. Newer antidepressants and the cytochrome P450 system Am J Psychiatry 1996 ; 28 : 241-7.Google Scholar
Pritchett, JTBernstein, JHKellner, CH. Combinded ECT and antidepressant drug therapy Convulsive Ther 1993 ; 9 : 256-61.Google Scholar
Sackeim, HA. Optimizing unilateral electroconvulsive therapy Convulsive Ther 1991 ; 7 : 201-12.Google ScholarPubMed
Selvin, BL. Electroconvulsive therapy-1987 Anesthesiology 1987 ; 67 : 367-85.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.