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1121 – Effects On Cognitive Function In Treatment Resistant Bipolar Depression: Ect Compared To Algorithm Based Pharmacological Treatment

Published online by Cambridge University Press:  15 April 2020

U. Kessler ,
H.K. Schoeyen ,
O.A. Andreassen ,
G.E. Eide ,
Å. Hammar ,
U.F. Malt ,
K.J. Oedegaard ,
G. Morken ,
K. Sundet  and
A.E. Vaaler
U. Kessler
Affiliation:
Moodnet Research Group, Haukeland University Hospital, Psychiatric Division Department of Clinical Medicine, Section of Psychiatry, University of Bergen, Bergen
H.K. Schoeyen
Affiliation:
Department of Clinical Medicine, Section of Psychiatry, University of Bergen, Bergen Moodnet Research Group, Psychiatric Division, Stavanger University Hospital, Stavanger
O.A. Andreassen
Affiliation:
Division of Mental Health and Addiction, Oslo University Hospital Institute of Clinical Medicine, University of Oslo, Oslo
G.E. Eide
Affiliation:
Centre for Clinical Research, Haukeland University Hospital Department of Public Health and Primary Health Care
Å. Hammar
Affiliation:
Moodnet Research Group, Haukeland University Hospital, Psychiatric Division Department of Biological and Medical Psychology, University of Bergen, Bergen
U.F. Malt
Affiliation:
Institute of Psychiatry, University of Oslo Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital, Rikshospitalet, Oslo
K.J. Oedegaard
Affiliation:
Moodnet Research Group, Haukeland University Hospital, Psychiatric Division Department of Clinical Medicine, Section of Psychiatry, University of Bergen, Bergen
G. Morken
Affiliation:
Department of Neuroscience, Faculty of Medicine, NTNU Division of Psychiatry, St. Olav's University Hospital, Trondheim
K. Sundet
Affiliation:
Institute of Clinical Medicine, University of Oslo, Oslo Department of Psychology, University of Oslo, Oslo, Norway
A.E. Vaaler
Affiliation:
Department of Neuroscience, Faculty of Medicine, NTNU Division of Psychiatry, St. Olav's University Hospital, Trondheim

Abstract

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Introduction

Electroconvulsive therapy (ECT) is a treatment alternative in bipolar disorder (BD) depression. Cognitive side effects are the major concern limiting its use.

Objectives

We present data from the Norwegian randomized controlled trial of ECT in treatment resistant depression in bipolar disorder.

Aims

To compare effects on cognitive function of ECT or algorithm based pharmacological treatment at the end of a six-week acute, BD depression treatment trial.

Methods

Prospective, randomised controlled multi-centre, six-week acute treatment trial. Pre- and post-treatment assessments with the MATRICS Consensus Cognitive Battery (MCCB); a neuropsychological test battery designed to be sensitive to changes in cognitive function.

Sample

N = 51 patients ≥ 18 years fulfilling criteria for treatment resistant BD depression (MADRS score ≥ 25).

Intervention

ECT group: Three sessions per week for up to six weeks, total up to 18 sessions, and right unilateral electrode placement. Algorithm-based pharmacological treatment group: Based on Goodwin & Jamison, 2007.

Results

Both groups showed a net gain on MCCB scores without significant differences between the study groups. Mean change in MCCB composite T-score was 4.0 (5.7) in the ECT group and 2.7 (3.6) in the pharmacological group (F = 0.78, eta2 = 0.021, p = 0.383).

Conclusion

In treatment resistant BD depression ECT and algorithm-based pharmacological treatment have comparable effects on cognitive function assessed with the MATRICS.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E512
Copyright
Copyright © European Psychiatric Association 2013
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