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The minimum alveolar concentration of sevoflurane in rats

Published online by Cambridge University Press:  16 August 2006

S. Kashimoto ,
A. Furuya ,
A. Nonaka ,
T. Oguchi ,
M. Koshimizu  and
T. Kumazawa
S. Kashimoto
Affiliation:
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan
A. Furuya
Affiliation:
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan
A. Nonaka
Affiliation:
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan
T. Oguchi
Affiliation:
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan
M. Koshimizu
Affiliation:
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan
T. Kumazawa
Affiliation:
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan
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Abstract

There are only limited data on sevoflurane minimum alveolar concentration (MAC) in rats. This study was designed to determine the minimum alveolar concentration value for sevoflurane in younger and older rats. Minimum alveolar concentration determination was performed in spontaneously breathing animals, 9-week-old rats (younger, n = 8) and more than 13-month-old rats (older, n = 8). Rats were instrumented with a silastic catheter in the abdominal aorta via the femoral artery to allow for arterial blood gas sampling. Subsequently, minimum alveolar concentration for sevoflurane was determined in 40 younger and 38 older rats. Minimum alveolar concentration for sevoflurane in younger rats was significantly higher than in the older rats (2.68 ± 0.19 vs. 2.29 ± 0.19, P < 0.001). Subgroup analysis indicated that minimum alveolar concentration for sevoflurane was not affected by the presence of an arterial catheter in the abdominal aorta (younger, 2.75 ± 0.08 vs. 2.67 ± 0.21; older, 2.23 ± 0.19 vs. 2.30 ± 0.18). Minimum alveolar concentration is profoundly affected by the age of the animal, but not by limited instrumentation.

Keywords

anaestheticsvolatilesevofluraneanimalsratpotencyanaestheticminimum alveolar concentration
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 4 , July 1997 , pp. 359 - 361
Copyright
1997 European Society of Anaesthesiology

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